| 杨 丽，艾文彬，罗 琴.头孢地尼与阿莫西林克拉维酸钾治疗儿童急性中耳炎的临床观察.[J].中南医学科学杂志.,2015,43(2):188-191. |
| 头孢地尼与阿莫西林克拉维酸钾治疗儿童急性中耳炎的临床观察 |
| Observation of Cefdinir with Amoxicillin/Clavulanatein in Treatment of Children Acute Otitis Media |
| 投稿时间：2014-02-13 |
| DOI： |
| 中文关键词: 头孢地尼 阿莫西林克拉维酸钾 急性中耳炎 儿童 |
| 英文关键词:cefdinir amoxicillin/clavulanate acute otitis media children |
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| 中文摘要: |
| 目的 比较头孢地尼与阿莫西林克拉维酸钾治疗儿童急性中耳炎（AOM）的疗效、用药依从性、安全性差别。 方法 对2011年1月～2012年12月资料完整的分别使用头孢地尼（日剂量7.0mg/kg，每日2次，连续服用5天，91例）或阿莫西林克拉维酸钾（日剂量13.3mg/kg，每日2次，连续服用10天，110例）治疗的AOM患儿进行回顾性分析。根据患儿临床症状与体征是否恢复评定疗效，比较两种药物对儿童AOM的疗效、药物依从性及安全性。 结果 头孢地尼组完成疗程的病例90例（106耳），治疗7～9天时有效率为98.11%（104/106耳）；阿莫西林克拉维酸钾组完成疗程的病例95例（106耳），治疗12～14天时有效率为90.57%（96/106耳）。头孢地尼组疗效明显高于阿莫西林克拉维酸钾组，差异具有显著统计学意义（P<0.05）。两组共有16例患儿药物依从性差未完成疗程，其中头孢地尼组1例，用药依从性为98.9%（90/91）；阿莫西林克拉维酸钾组15例，用药依从性为86.4%（95/110），两组比较有显著性差异（P<0.05）；两组共有6例患儿出现不良反应，包括皮疹、腹泻及恶心反应；其中头孢地尼组2例，不良反应发生率为2.2%（2/91）；阿莫西林克拉维酸钾组4例，不良反应发生率为3.6%（4/110）；两组比较无显著性差异（P＞0.05）。 结论 与阿莫西林克拉维酸钾10天疗法相比，头孢地尼5天疗法药效、用药依从性均较好，不良反应少而轻微，是短程治疗儿童AOM的一个很好选择。 |
| 英文摘要: |
| Objective To compare the efficacy,safety,compliance difference of cefdinir and amoxicillin/clavulanate in treatment of children with acute otitis media（AOM）. Methods 201 cases （232 ears） with AOM who received either cefdinir particles （daily dose of 7mg/kg/d,divided two times daily for 5 days） or amoxicillin/clavulanate（daily dose of 13.3 mg/kg,divided two times daily for 10 days） treatment from 2011 January to 2012 December were reviewed retrospectively.According to the clinical symptoms and signs recovery,compare the efficacy,drug compliance and safety differences of two groups. Results At the end of treatment,104 ears were cured or improved （104/106，98.11%） in the cefdinir group,while in the amoxicillin/clavulanate group 96 ears were cured or improved （96/106，90.57%）.Cefdinir was significantly better than amoxicillin/clavulanate in efficacy （P<0.05）.Totally 16 cases had poor medication adherence,1 case in the cefdinir group,other 15 cases in the amoxicillin/clavulanate group.The medication compliance of the Cefdinir group was 98.9%（90/91）,amoxicillin/clavulanate group was 86.4%（95/110）,there was significant difference between two groups （P<0.05）.Totally 6 cases appeared adverse reactions,including skin rash,diarrhea and nausea,2 cases in the cefdinir group,other 4 cases in the amoxicillin/clavulanate group.The rate of adverse reaction in the Cefdinir group was 2.2%（2/91）,the amoxicillin/clavulanate group 3.6%（4/110）,two groups had no significant difference （P>0.05）. Conclusion 5-day oral cefdidir treatment was significantly better than 10-day oral amoxicillin/clavulanate treatment for children acute otitis media in efficacy、medication adherence and safety,it seems to be a better choice of short treatment. |
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