| 符青云，黄世章，欧阳小明.宫颈高级别上皮内病变Leep术后标本病理观察与分析.[J].中南医学科学杂志.,2015,43(2):172-174. |
| 宫颈高级别上皮内病变Leep术后标本病理观察与分析 |
| Clinicopathological Analysis and Observation of Specimen after Leep Operation in Cervical Intraepithelial Neoplasia Ⅲ |
| 投稿时间：2014-01-15 |
| DOI： |
| 中文关键词: 宫颈 高级别上皮内病变 CINⅢ 累及腺体 Leep术 |
| 英文关键词:cervical high grade intraepithelial lesion CIN3 involvement of glands Loop electrosurgical excision |
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| 中文摘要: |
| 目的 通过总结宫颈高级别上皮内病变（CINⅢ）宫颈锥切术（Leep）术后标本的病理组织学特点，为合理选择Leep术治疗CINⅢ提供依据。 方法 收集宫颈多点活检诊断CINⅢ后再行Leep术后的标本经病理确诊的196例患者资料，重新阅读病理切片、诊断，并复习文献，进行分析、总结其病理组织学特点。 结果 年龄≤40岁者118例（60.2%），41～60岁者61例（31.1%），＞60岁者17例（8.7%）。最后病理诊断CINⅢ累腺88例（44.9%）、CINⅢ未累腺108例（54.1%）；其中，合并浸润性鳞状细胞癌分别为18.2%（16/88）和4.6%（5/108）、伴间质微小浸润分别为23.9%（21/88）和6.5%（7/108），标本切缘有瘤组织残留分别为10.2%（9/88）和5.6%（6/108），上述各项病理诊断结果比较差异有统计学意义（χ224.279，P0.00）。CINⅢ累腺33例做HPV标记，阳性26例（78.9%），CINⅢ未累腺28例做HPV标记，阳性12例（42.9%）。 结论 CINⅢLeep术后标本病理组织学诊断全面、准确、可靠，较显著特点是CINⅢ伴腺体累及和间质微小浸润，对合理选择Leep术治疗CINⅢ有实际指导意义。 |
| 英文摘要: |
| Objective To sum up the pathological characteristics of cervical intraepithelial neoplasia III （CIN3） after Leep operation to lay down a foundation of Leep operation. Methods One hundred and ninety six cases of CIN3 were collected by confirmation of biopsy of multiple points and treated by Leep operation.The final diagnosis was verified by pathological examination of the specimen.All the data were analyzed and summaried in combination with literatures. Results There were 118 cases in the age no more than 40 years （60.2%） and 61 cases in the age of 41 to 60 years （31.1%） and 17 cases in the age of more than 60 years （8.7%）.The final diagnosis:there were 88 cases （44.9%） involving surrounding glands and 108 cases non-involving surrounding glands （54.1%）.Among them,16 cases （18.2%） of 88 and 5 cases （4.6%） of 108 were combined with infiltrated squamous cell cancer21 cases （23.9%） of 88 and 7 cases （6.5%） of 108 were combined with interstitial minor infiltrated cancer9 cases （10.2%） of 88 and 6 cases （5.6%） of 108 had tumor residual in the margin of specimen （P0.00）.In addition,HPV mark was processed in 33 cases which involved the surrounding glands in positive rate of 78.9% （26 cases）,and in 28 cases which did not involve the surrounding glands in positive rate of 42.9% （12 cases）. Conclusion The pathological diagnosis of CIN3 of specimen is accurate and reliable in proof of involvement of glands and interstitials for Leep operation. |
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