| 周 静，廖宏庆，周 俊，聂玉林.解冻囊胚体外培养时间与妊娠结局的关系.[J].中南医学科学杂志.,2015,43(2):150-152. |
| 解冻囊胚体外培养时间与妊娠结局的关系 |
| Effect of the Culture Time for Thawed Blastocysts on Pregnancy Outcome |
| 投稿时间：2014-07-14 |
| DOI： |
| 中文关键词: 冻融囊胚移植 临床妊娠率 种植率 |
| 英文关键词:frozen-thawed blastocyst transfer clinical pregnancy rate implantation rate |
| 基金项目:国家自然科学基金（31371277）. |
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| 中文摘要: |
| 目的 比较冻融囊胚周期解冻后体外培养的时间对妊娠结局的影响。 方法 回顾性分析155例首次接受冻融胚胎移植周期（FET）的患者，其中38个囊胚解冻周期在排卵或肌注黄体酮后4天进行解冻复苏，培养16～18 h后进行移植（16～18 h组），117个囊胚解冻周期在排卵或肌注黄体酮后4天进行解冻，培养2～3 h后移植（2～3 h组），对两组患者平均年龄、原发不孕比例、自然周期比例、移植胚胎枚数、移植优质囊胚比例、移植日内膜厚度、临床妊娠率、胚胎种植率、流产率等数据进行对照分析。 结果 两组患者平均年龄、原发不孕比例、自然周期比例、移植胚胎枚数、移植优质囊胚比例、移植日内膜厚度均无统计学差异（P>0.05），16～18 h组临床妊娠率、种植率与2～3 h组无统计学差异（P>0.05）；16～18 h组的流产率显著高于2～3 h组（P<0.05）。 结论 解冻囊胚培养2～3 h移植，能够有效降低流产率，改善妊娠结局。 |
| 英文摘要: |
| Objective To explore the effect of culture time in vitro of thawed blastocysts on pregnancy outcome. Methods The frozen-thawed blastocysts which were thawed at 4 days after ovulation or intramuscular injection of progesterone were selected as study objects，155 patients receiving frozen-thawed embryos transfer （ FET） for the first time were analyzed retrospectively.38 patients receiving FET at 16～18 hours after thawing were selected as 16～18 hours culture group，117 patients receiving FET at 2～3 hours after thawing were selected as 2～3 hours culture group.The average age of the two groups of patients,the proportion of primary infertility,the proportion of the natural cycle,number of transfer embryos,the proportion of high quality transfer blastocyst,and endometrial thickness on transfer day,clinical pregnancy rate,implantation rate,abortion rate data were compared. Results There were no statistical differences between two groups on the average age of the two groups of patients,the proportion of primary infertility,the proportion of the natural cycle,number of transfer embryos,the proportion of high quality transfer blastocyst,and endometrial thickness on transfer day （P>0.05）.The clinical pregnancy rate and implantation rate had no statistical differences between 16～18 hours culture group and 2～3 hours culture group （P>0.05）the abortion rate in 2～3 hours culture group was significant lower than that in 16～18 hours culture group （ P< 0.05）. Conclusion Thawed blastocysts cultured for 2～3 hours to transfer could effectively reduce the abortion rate and improve pregnancy outcome. |
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