| 王俞方，夏世刚，罗洁，陈磊，燕建军.长期配戴硬性角膜接触镜对泪膜稳定性的影响.[J].中南医学科学杂志.,2015,43(1):63-66. |
| 长期配戴硬性角膜接触镜对泪膜稳定性的影响 |
| Effect of Long-term Wearing Rigid Contact Lenses on the Stability of Tear Film |
| 投稿时间：2014-08-21 |
| DOI： |
| 中文关键词: 角膜接触镜 泪膜稳定性 泪膜破裂 |
| 英文关键词:contact lenses the stability of tear film BUT |
| 基金项目: |
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| 中文摘要: |
| 目的探讨长期配戴硬性角膜接触镜对泪膜稳定性的影响。方法选取80例（160眼）患者分成四组：硬性角膜接触镜（RGP组）：长期配戴RGP（20例，40眼）；角膜塑形镜组：长期夜间配戴角膜塑形镜（22例，44眼）；软性接触镜组：长期配戴软性接触镜（20例，40眼）；对照组：为无角膜接触镜配戴史的低度近视患者（18例，36眼），分别在戴镜前和戴镜后1个月、6个月、1年、2年检测视力，施墨（SchirmerI）试验检测泪腺分泌功能，泪膜破裂时间（BUT）测定泪膜破裂时间，结膜印迹细胞学（CIC）观察结膜表层细胞形态学改变及结膜杯状细胞数目，泪膜羊齿状实验评估泪液中蛋白质含量的变化，观察结果进行统计学分析。结果各实验组的泪腺分泌功能和泪膜破裂时间均降低，与对照组间比较差异有统计学意义（P<0.05），各实验组长期持续配戴角膜接触镜后结膜杯状细胞减少，且不能形成良好的蕨样变现象。结论长期配戴角膜接触镜可致泪膜稳定性下降，泪液分泌量减少。 |
| 英文摘要: |
| Objective To investigate the effect of long-term wearing rigid contact lenses on the stability of tear film.Methods Eighty （one hundred sixty eyes） patients were randomly divided into four groups:Group one,Long-term wearing RGP （twenty patients,forty eyes） Group two,Long-term wearing orthokeratology lenses at night （twenty-two patients,forty-four eyes） Group three,Long-term wearing soft contact lenses （twenty patients,forty eyes） Normal control,low myopia patients without a history of wearing contact lenses （eighteen patients,thirty-six eyes）.Patients' vision,Schirmer I test,break-up time （BUT） of tear film,conjunctival impression cytology （CIC）,and tear film fern experiments were performed before wearing lenses,wearing for one month,wearing for six month,wearing for one year,wearing for two years,respectively. Results The results of Schirmer I test and break-up time （BUT） of tear film in each experimental group were reduced as compared with normal control group.The difference was statistically significant （P<0.05）.After long-term wearing contact lenses,the conjunctival goblet cells was decreased in all experimental groups,and can not form a good ferning phenomenon. Conclusions Long-term wearing contact lenses can result in decreasing the stability of tear film and reduce tear secretion. |
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