| Objective To study the hepatic protection effect of Scutellaria Baicalensis Total Flavonoid （SBTF）. Methods Seventy male Kunming mice were randomly divided into seven groups:blank control group,model group,negative group,bifendate positive group and high-dose,middle-dose,low-dose group.Stomach perfusion was given for 15 days High-dose,middle-dose,low-dose group were given SBTF 400mg/kg，200mg/kg，100mg/kg each once a day positive group,negative group,model group and blank control group were given bifendate（200mg/kg）,poloxamer solution（2.0%）,normal saline separately.At the 15th day,6 hours after perfusion,all mice were intraperitoneally injected carbon tetrachloride oil resolution （0.1%） except the blank group,and 12h later,mice were weighed and taken for blood their livers were separated,taking pictures,making homogenate to test MDA.The whole blood was centrifugalled and blood serum was to test ALT and AST and calculate liver index. Result For positive and high-dose group,the surface of mice's liver was smooth and ruddy with no blood clot or spots,but a little dull compared with blank control group middle-dose and low-dose group had less ruddy sequence with more obvious blood spots negative and model group were pale,with block of clots and spots.AST,ALT,MDA of negative and model group were apparently higher than blank control group decreases in the sequent low-dose,middle-dose,high-dose group,but not so evident as positive group. Conclusion SBTF has a hepatoprotection effect,positively related to its dose. |