| 李小红，杨沁，危当恒.TET2：潜在的动脉粥样硬化表观遗传生物标记物和治疗靶点.[J].中南医学科学杂志.,2015,43(1):5-8. |
| TET2：潜在的动脉粥样硬化表观遗传生物标记物和治疗靶点 |
| TET2:a Potential Epigenetic Biomarker and |
| 投稿时间：2014-05-29 |
| DOI： |
| 中文关键词: 甲基双加氧酶TET2 动脉粥样硬化 表观遗传 生物标记物 |
| 英文关键词:TET2 atherosclerosis epigenetic biomarker |
| 基金项目:National Natural Science Foundation of China （81370378） and the construct program of the key discipline in Hunan province. |
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| 中文摘要: |
| 动脉粥样硬化是一种慢性炎症性的病理改变，是心血管疾病最主要的病因，寻找新的生物标记物对有效诊断和治疗动脉粥样硬化有非常重要的作用。最新研究发现在很多肿瘤疾病中出现了TET2的功能缺失或异常。甲基双加氧酶TET2为TET蛋白家族成员，主要功能为催化5甲基胞嘧啶（5mC）生成5羟甲基胞嘧啶（5hmC），参与DNA的去甲基化和修复及基因组的稳定。DNA甲基化模式的改变发生于动脉粥样硬化的发生发展过程中。最近的研究表明，TET2在造血干细胞的自我更新及分化过程中起着非常重要的作用，TET2突变及功能失调与多种疾病，特别是血液性疾病的发生、发展密切相关。基于TET2的生物学作用，我们推测TET2可能是动脉粥样硬化的理想的表观遗传学生物标记物以及防治的靶点。 |
| 英文摘要: |
| Atherosclerosis,a slow and progressive pathological change,is the usual cause of cardiovascular diseases.Finding new biomarkers focusing on the nature of atherosclerosis is necessary to effectively diagnose and prevent clinical events.Recent studies find the functions of TET2 are deficient or aberrant in many neoplastic disorders.Ten-eleven-translocation 2 （TET2） is a member of the TET family that functions as a regulator of DNA methylation by oxidizing 5-methylcytosine （5mC） to 5-hydroxymethylcytosine （5hmC）,which contributes to DNA demethylation,repair,and genomic stability.DNA methylation pattern alterations occur in the development of atherosclerosis.Recent studies demonstrated that TET2 has a significant function in the self-renewal and differentiation of hematopoietic stem cells.Its mutation and dysfunction contribute to numerous specific diseases,such as hematopoiesis and hematopoietic diseases.Based on its biochemical,genetic,and functional implications,TET2 is a potential “ideal” epigenetic biomarker and therapeutic target for atherosclerosis. |
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