| 曾群，彭华保，龚晓琴，侯彰华，黄芳，邝晓敏.新生儿导管相关性血流感染病原学分布及耐药性分析.[J].中南医学科学杂志.,2014,42(5):500-503. |
| 新生儿导管相关性血流感染病原学分布及耐药性分析 |
| Analysis of Pathogens and Drug Resistance of Catheter-related Bloodstream Infection in Newborn Infants |
| 投稿时间：2014-04-08 |
| DOI： |
| 中文关键词: 经外周中心静脉置管 脐静脉置管 导管相关性血流感染 新生儿 |
| 英文关键词:PICC UVC CRBSI Neonate |
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| 中文摘要: |
| 目的探讨新生儿重症监护室（NICU）导管相关性血流感染（CRBSI）病原学分布及耐药情况。方法 |
| 英文摘要: |
| ObjectiveTo investigate the distribution of causative agents and their antibiotic susceptibility patterns of catheter-related blood stream infection (CRBSI) in neonatal intensive care unit (NICU) patients.MethodsA retrospective analysis was performed on 323 neonates in NICU who received peripherally inserted central catheter (PICC group,n=268) and received umbilical venous catheter (UVC group,n=104) from January 2011 to April 2013.The incidence,clinical features and causative pathogens of CRBSI,as well as antibiotic susceptibility,were investigated.ResultThe CRBSI rate in our NICU was 6.1 per 1 000 catheter-days.The incidence of PICC-associated CRBSI was 5.3 per 1 000 catheter-days,and UVC- associated CRBSI was 11.8 per 1 000 catheter-days.A total of 35 blood and catheter tip cultures were positive for bacterial growth,of which 22 were fungi,8 were Gram-negative bacteria and 5 were Gram-positive bacteria.Of the 22 isolated fungi,17 (48.57%) were Candida albicans as the leading cause of bacteremia.Klebsiella pneumoniae(14.29%) were the common cause of Gram-Negative bacillus,and Staphylococcus epidermidis(8.57%) were the predominant agents of Gram-positive bacteria.Most of the fungi were susceptible to Amphotericin and Fluconazole.Gram-negative bacillus were resistant to the Ampicillin and Cephalosporins,while sensitive to Carbapenem,Piperacillin-tazobactam and Quinolones;Gram-positive bacteria were against Penicillin G,Oxacillin and Cephalosporins,and remained sensitive to Vancomycin and Quinolones.ConclusionThe most common pathogens of CRBSI were Candida albicans which were highly sensitive to Fluconazole in our NICU,followed by Klebsiella pneumoniae,and the drug resistance of them were more serious. |
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