| 周君，何红晨,肖登,陈世菊,刘慧芳,覃渝茜,何成奇.脉冲电磁场联合电针疗法对去卵巢大鼠骨质疏松的影响.[J].中南医学科学杂志.,2014,42(4):331-335. |
| 脉冲电磁场联合电针疗法对去卵巢大鼠骨质疏松的影响 |
| Effects of Combination Treatment with Pulsed Electromagnetic Fields and Electroacupuncture on Ovariectomy-induced Osteoporosis in Rats |
| 投稿时间：2013-11-11 |
| DOI： |
| 中文关键词: 骨质疏松 骨密度 生物力学 脉冲电磁场 电针 联合治疗 |
| 英文关键词:osteoporosis bone mineral density bone biomechanical properties pulsed electromagnetic fields electroacupuncture combination treatment |
| 基金项目:国家自然科学基金资助项目（81171865），湖南省卫生厅资助项目（B2014-052）. |
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| 中文摘要: |
| 目的探索脉冲电磁场联合电针疗法对去卵巢大鼠骨质疏松的影响。方法将50只SD雌性大鼠随机分为假手术组、去势组、脉冲电磁场组、电针组和联合组，每组10只。除假手术组外，各组大鼠行双侧卵巢切除术，假手术组大鼠只切除卵巢周围与卵巢大小相仿的脂肪组织。去除卵巢术后1周，假手术组和去势组不作任何干预，脉冲电磁场组给予脉冲电磁场治疗、电针组给予电针治疗，联合组同时给予脉冲电磁场和电针治疗。干预12周后处死实验动物，取左股骨和L5椎体进行骨密度检测及生物力学检测；取左胫骨观察组织形态学变化。 |
| 英文摘要: |
| ObjectiveTo explore whether combination treatment with pulsed electromagnetic fields (PEMFs) and electroacupuncture (EA) have additive benefits on bone mineral density(BMD) and biomechanical properties in OVX rats.MethodsFifty 3-month old female Sprague-Dawley rats were assigned to one of five groups:sham-operated control (Sham),ovariectomy (OVX),ovariectomy with PEMFs treatment (PEMFs),ovariectomy with EA treatment (EA),and ovariectomy with PEMFs+EA treatment (PEMFs+EA).After 12-week treatments,bone mineral density,histomorphometric parameters,and bone biomechanical properties were examined.ResultsPEMFs,EA and combination treatment significantly increased BMD of the femur (P<0.01,P<0.05) compared to OVX group.There was no significant difference in the femur BMD among the five groups(P>0.05).PEMFs,EA and combination treatment significantly increased BMD of L5 vertebral body (P<0.01) compared to OVX group.Whats more,combination treatment with PEMFs and EA was more effective than PEMFs or EA alone for improving BMD in L5 vertebral body(P<0.05).The biomechanical three-point bending experiment showed that PEMFs and combination treatment significantly increased maximum load in the left femur compared to OVX group (P<0.05).There was no significant difference in maximum load of the left femur among the five groups(P>0.05).The compression test showed that PEMFs,EA and combination treatment significantly increased maximum load (P<0.01) and energy to failure (P<0.01) in L5 vertebral body compared to OVX group.Whats more,combination treatment was more effective than PEMFs or EA alone for improving maximum load (P<0.05,P<0.01) and energy to failure (P<0.01) in L5 vertebral body.ConclusionsCombination treatment with PEMFs and EA have additive benefits on BMD and bone biomechanical properties in the lumbar vertebral body. |
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