| 陈景，唐东兴，张琳，章可铸.骨化三醇联合鲑鱼降钙素治疗肾性骨病的临床疗效分析.[J].中南医学科学杂志.,2014,42(3):284-286. |
| 骨化三醇联合鲑鱼降钙素治疗肾性骨病的临床疗效分析 |
| Therapeutic Analysis of Combination of Calcitriol and Salmon Calcitonin on Renal Osteodystrophy |
| 投稿时间：2013-05-13 |
| DOI： |
| 中文关键词: 骨化三醇 鲑鱼降钙素 肾性骨病 |
| 英文关键词:calcitriol salmon calcitonin renal osteodystrophy |
| 基金项目: |
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| 中文摘要: |
| 目的分析骨化三醇和鲑鱼降钙素联合治疗肾性骨病的临床疗效。方法回顾分析2010年1月～2012年12月在本院治疗的肾性骨病患者30例，选择经骨化三醇联合鲑鱼降钙素治疗患者为治疗组，单纯运用骨化三醇治疗的患者为对照组，每组15例。比较两组临床疗效、生化指标改善情况及不良反应发生情况。结果两组患者治疗后骨痛、关节痛、皮肤瘙痒等临床症状均较治疗前有不同程度的改善，联合组患者临床总有效率明显高于对照组（P＜0.05）。两组患者治疗后血清磷和PTH水平均较治疗前有不同程度的下降，而血清钙水平较治疗前有不同程度的升高（P＜0.05）。两组患者服药期间未发现明显不良反应。结论骨化三醇联合鲑鱼降钙素治疗肾性骨病，可有效缓解患者骨痛、关节痛、皮肤瘙痒等临床症状，可在临床中推广应用。 |
| 英文摘要: |
| ObjectiveTo analyse the clinical efficacy of the calcitriol and salmon calcitonin combination therapy on renal osteodystrophy.Method30 patients suffered from renal osteodystrophy were treated with calcitriol (control group，n=15) or calcitriol and salmon calcitonin (CSC group，n=15)，respectively.The clinical efficacy，biochemical indicators and adverse reactions were compared.ResultsBone pain，joint pain，skin itching and other symptoms after treatment have improved compared with those before treatment.The total clinical effective rate in CSC group was significantly higher than that in the control group (P<0.05).After treatment，the serum phosphorus and PTH levels were decreased in varying degrees compared with that before treatment and serum calcium levels were elevated (P<0.05).Indicators of treatment group improved more obviously compared with that in control group (P<0.05).No adverse effects were found in the two groups during the medication.ConclusionCombination of calcitriol and salmon calcium in treatment of renal osteodystrophy can effectively alleviate the clinical symptoms，such as bone pain，joint pain，and itchy skin，etc，which is worthy of being recommended. |
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