谭湘芳,罗志刚,王毅,李建军,钱坤,李跃进.CMV-PP65抗原检测在预防肾移植术后巨细胞病毒感染的临床价值.[J].中南医学科学杂志.,2013,41(6):570-571. |
CMV-PP65抗原检测在预防肾移植术后巨细胞病毒感染的临床价值 |
The Clinical Value of CMV-PP65 Antigen Detection in the Prevention ofCytomegalovirus Infection After Renal Transplantation |
投稿时间:2013-09-09 |
DOI: |
中文关键词: 肾移植 巨细胞病毒PP65 巨细胞病毒IgM抗体 |
英文关键词:renal transplantation cytomegalovirus PP65 cytomegalovirus IgM antibody |
基金项目:衡阳市科委资助课题(2008KS022). |
|
摘要点击次数: 956 |
全文下载次数: 965 |
中文摘要: |
目的探讨巨细胞病毒PP65抗原(CMV-PP65)检测在预防肾移植术后巨细胞病毒(CMV)感染的临床价值。方法采用间接免疫荧光法和酶联免疫捕获法检测52例肾移植受者术后CMV-PP65抗原和CMV-IgM抗体。结果52例肾移植受者中CMV-PP65抗原检测阳性25例,CMV-IgM抗体检测阳性17例,随访3~6个月,共15例发生CMV病,CMV-PP65抗原检测均阳性,CMV-PP65抗原检测的敏感度及阴性预测值均高于CMV-IgM抗体检测;25例患者CMV-PP65抗原检测术后首次出现阳性的平均时间为4.2±3.3周,17例患者CMV-IgM抗体检测术后首次出现阳性的平均时间为8.7±5.8周,两者比较有显著差异性(P<0.05)。结论CMV-PP65抗原检测可早期排除和预防肾移植术后CMV感染,值得临床推广应用。 |
英文摘要: |
ObjectiveTo investigate the clinical value of CMV-PP65 antigen detection in the prevention of cytomegalovirus infection after renal transplantation.MethodsThe CMV-PP65 antigen and CMV-IgM antibody of 52 cases with renal transplantation recipients were detected with the method of indirect immunofluorescence and enzyme-linked immune capture.ResultsAmong the 52 cases of kidney transplant,25 cases were tested positive with CMV-PP65 antigen,17 cases were tested positive with CMV-IgM antibody.All patients were followed up for 3~6 months,CMV occurred in 15 cases,and their CMV-PP65 antigen were detected positive,the detection sensitivity and negative predictive value of CMV-PP65 antigen detection were higher than that of CMV-IgM antibody detection.The average length for the first postsurgical positive detection of CMV-PP65 antigen with 25 cases was 4.2±3.3 weeks,while that of the CMV-IgM antibody with 17 cases was 8.7±5.8 weeks,with a significant difference between them (P<0.05).ConclusionCMV-PP65 antigen detection could be employed for the early elimination and prevention of CMV infection after renal transplantation.It was worthy of clinical popularization and application. |
查看全文 查看/发表评论 下载PDF阅读器 |
关闭 |