| 曾凤，卢亚梅，周元清，陈永铃.氯替泼诺治疗中重度干眼抗炎作用的临床分析.[J].中南医学科学杂志.,2013,41(5):486-489. |
| 氯替泼诺治疗中重度干眼抗炎作用的临床分析 |
| Clinical Research of Anti-inflammatory Effects of LoteprednolTreat Moderate to Severe Dry Eye |
| 投稿时间：2013-05-09 |
| DOI： |
| 中文关键词: 干眼 氯替泼诺 炎症介质 |
| 英文关键词:dry eye loteprednol inflammatory mediators |
| 基金项目: |
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| 摘要点击次数: 1150 |
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| 中文摘要: |
| 目的观察0.5％氯替泼诺滴眼液治疗中重度干眼病的临床疗效。方法按标准纳入中重度干眼患者40例，回顾性分两组：联合用药组予0.5％氯替泼诺滴眼液和新泪然滴眼液联合用药；单用药组用新泪然滴眼液。在治疗前及治疗后2、4、6周观察眼表疾病指数（OSDI）、泪膜破裂时间（BUT）、泪液分泌实验（Schirmer I试验）、眼表染色评分（OSS评分）、眼压；ELISA测泪液中炎症介质白介素-6（IL-6）的表达。结果治疗2周后，联合用药组OSDI评分均值明显降低，较治疗前差异有显著性(P＜0.05)；治疗2周联合用药组眼表炎症体征减轻；联合用药组BUT均较治疗前延长；两组各时间点的Sehirmer I及眼压值无明显变化。结论0.5％氯替泼诺滴眼液通过下降IL-6表达，减轻中重度干眼眼表炎症，安全有效。 |
| 英文摘要: |
| ObjectiveTo observe the effect of 0.5% loteprednol eye drops on the clinical efficacy of moderate-severe dry eye and investigate the potential mechanism of loteprednol eye drops in anti-inflammation.Method40 cases of moderate-severe dry eye patients according to the clinical standards were randomly divided into two groups:Experimental group (0.5% loteprednol eye drops together with Hypromellose 2910 eye drops);The control (Hypromellose 2910 eye drops).After treatment of loteprednol eye drops for 2,4,6weeks,and ocular Surface Disease Index(OSDI),tear film break-up time(BUT),Schirmer test I(Schirmer I test),ocular surface staining(OSS) score and intraocular pressure were observed,the IL-6 expression in the tear fluid was detected by Enzyme-linked immunosorbent assay (ELISA).ResultAfter two weeks of treatment,the OSDI mean score of experimental group was significantly reduced,the difference was statistically significant(P＜0.05) than before treatment,and ocular inflammation signs of experimental group was alleviated;BUT of Experimental group was extended than before treatment;Sehirmer I and NCT in two groups at each time point were not significantly changed.Conclusions0.5% loteprednol eye drops could decrease the expression of IL-6 and relieve the symptom of moderate to severe dry eye ocular inflammation;so it is safe and effective. |
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