杨红霞,蒋恒波.倍博特对原发性高血压患者血压变异性的影响.[J].中南医学科学杂志.,2013,41(4):379-381.
倍博特对原发性高血压患者血压变异性的影响
Effects of the Fixed-dose Combination of Valsartan/Amlodipine on Blood Pressure Vari-ability(BPV) of Patients with Primary Hypertension
投稿时间:2013-04-03  
DOI:
中文关键词:  倍博特  原发性高血压  血压变异性
英文关键词:fixed-dose combination of Valsartan/Amlodipine  primary hypertension  blood pressure variability
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作者单位
杨红霞,蒋恒波 永州职业技术学院,湖南 永州 425100 
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中文摘要:
      目的观察倍博特对原发性高血压患者血压变异性的影响。方法将191例原发性高血压患者回顾性分为倍博特组64例,缬沙坦组64例和氨氯地平组63例,给药前和给药8周后,分别动态血压监测各组患者,观察倍博特对血压变异性的影响。结果3组治疗8周后,与治疗前相比,24 h平均收缩压(24 hSBP)、24 h平均舒张压(24 hDBP)、24 h平均收缩压变异性(24 hSBPV)、24 h平均舒张压变异性(24 hDBPV)均明显下降(P<0.05);与缬沙坦组和氨氯地平组比较,倍博特组的24 hSBPV下降显著,差异有显著性(P<0.05),但24 hDBPV的改变不明显((P>0.05)。结论倍博特可以降低原发性高血压患者的收缩压变异性,具有良好的降压作用。
英文摘要:
      ObjectiveTo evaluate the effect of the fixed-dose combination of Valsartan/Amlodipine on blood pressure vari-ability(BPV)of patients with primary hypertension.Methods191 patients with primary hypertension were included in this study,which were randomly divided into the fixed-dose combination of Valsartan/Amlodipine,Valsartan and Amlodipine group.Before the treatment and 8 weeks after treatment,the BPV of all the patients was measured by ambulatory blood pressure monitoring.ResultsAt 8 weeks,24-hour systolic blood pressure,24-hour diastolic blood pressure,blood variability of systolic blood pressure and blood variability of diastolic blood pressure decreased significantly (P<0.05) compared with pre-treatment level.Compared with Valsartan and Amlodipine group,blood variability of systolic blood pressure in the fixed-dose combination of Valsartan/Amlodipine group was significantly lower,while blood variability of diastolic blood pressure was similar among three groups after 8 weeks.ConclusionValsartan/Amlodipine has smooth control effect on patients with primary hypertension through lowering the variability of systolic blood pressure.
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