| 林浩，熊石龙.2型糖尿病肾病患者血清脂蛋白(a)和超敏C反应蛋白的变化及其相关性分析.[J].中南医学科学杂志.,2013,41(4):375-378. |
| 2型糖尿病肾病患者血清脂蛋白(a)和超敏C反应蛋白的变化及其相关性分析 |
| The Changes of Serum Lipoprotein(a) and High Sensitivity CRP Levels and Their Relation in Patients with Type 2 Diabetic Nephropathy |
| 投稿时间：2012-12-26 |
| DOI： |
| 中文关键词: 2型糖尿病肾病 脂蛋白(a) 超敏C反应蛋白 尿白蛋白排泄率 |
| 英文关键词:type 2 diabetic nephropathy serum lipoprotein(a) hs－CRP urinary album in excretion rate |
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| 中文摘要: |
| 目的分析2型糖尿病肾病患者（T2DN）血清脂蛋白(a)和超敏C反应蛋白（hs－CRP）浓度的变化及其相关性，探讨血清脂蛋白(a)和hs－CRP水平在早期诊断T2DN中的作用及意义。 方法根据24 h尿白蛋白排泄率(UAER)不同将72例2型糖尿病患者分为单纯糖尿病组(SDM组)35例（UAER <30 mg/24 h）、早期糖尿病肾病组(EDN组)20例（UAER为30～300 mg/24 h）和临床糖尿病肾病组(CDN组)17例（UAER >300 mg/24 h），同时选择50例健康体检者作为对照组（NC组）。检测各组血清脂蛋白(a)、hs－CRP及总胆固醇(TC)、甘油三酯(TG)和糖化血红蛋白（HbA1c）水平，并对脂蛋白(a)、hs－CRP与UAER进行相关性分析。 结果与对照组比较，糖尿病患者TC、TG、脂蛋白(a)、hs－CRP及HbA1c水平均显著升高(P<0.01)；糖尿病患者不同组间比较，随着HbA1c、UAER的增加，脂蛋白(a)、hs－CRP水平呈递增改变（P<0.01)。脂蛋白(a)和hs－CRP水平与UAER呈显著正相关(r=0.387,P<0.05；r=0.782，P<0.01)，脂蛋白(a)与hs－CRP变量间呈显著正相关(r= 0.793，P<0. 05)。 结论脂代谢紊乱是T2DN的危险因素，血清脂蛋白(a)和hs－CRP水平在T2DN早期即发生改变，与T2DN的分期相关。同时检测血清脂蛋白(a)和hs－CRP对T2DN的早期诊断具有一定的临床价值。 |
| 英文摘要: |
| Objective To analyze the levels of serum lipoprotein(a)［Lp(a)］ and high sensitivity CRP(hs－CRP) and their correlation in patients with type II diabetic nephropathy(T2DN), and explore the role and significance of serum Lp(a) and hs－CRP levels in the early diagnosis of T2DN. Methods 72 patients with type II diabetes mellitus were divided into three groups according to the results of 24h urinary album in excretion rate(UAER), SDM, EDN and CDN group, with 50 healthy cases as control group. The serum Lp(a), hs－CRP, total cholesterol(TC), triacylglyccrol(TG) and glycated hemoglobins (HbA1c) were measured by standard method, and the results were analyzed statistically. ResultsThe levels of TC, TG， Lp(a), hs－CRP, and HbA1c were higher significantly in patients with T2DM than those in the control group(P<0.05). Among SDM, EDN and CDN groups, the levels of Lp(a) and hs－CRP got progressively higher with the increase of HbA1c and UAER(P<0.01). There were linear positive correlation between the serum Lp(a), hs－CRP and UAER levels (r=0.387,P<0.05 ;r=0.782，P<0.01)，and there was linear correlation between Lp(a) and hs－CRP (r= 0.793，P<0. 05) . ConclusionLipid metabolism disorder is a risk factor for T2DN, the levels of serum Lp(a) and hs－CRP are related with the degree of DN, combined determination of serum Lp(a) and hs－CRP has positive effects on early diagnosis of T2DN. |
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