| 肖和龙，琚雄飞，马剑玲，段文琴，邓勍,邹冬梅,陈敏敏.惠州市成年女性HPV感染及其基因型分布.[J].中南医学科学杂志.,2013,41(4):361-364. |
| 惠州市成年女性HPV感染及其基因型分布 |
| The Study of HPV Infection and Genotype Among Adult Female in Huizhou City |
| 投稿时间：2013-04-06 |
| DOI： |
| 中文关键词: 宫颈癌 HPV 基因型 |
| 英文关键词:cervical cancer human papilloma virus genotype |
| 基金项目:惠州市科委资助项目(20110807）. |
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| 中文摘要: |
| 目的了解本辖区成年女性HPV感染状况及人乳头瘤病毒（HPV）基因型分布，为宫颈癌筛查及防控策略提供科学依据。 方法收集2009年1月～2011年12月间惠州市部分医院妇科门诊妇检人群宫颈脱落细胞有效标本5 860份，其中宫颈上皮内瘤变Ⅰ（CINI）47例、CINⅡ49例、CINⅢ38例，宫颈癌4例，应用核酸分子杂交技术检测HPV基因型。结果5 860例标本中，HPV阳性1 154例，HPV阳性率19.7%，<20岁年龄组、20岁～年龄组和50～60岁年龄组阳性率较高，分别达23.7%、20.2%和22.8%。共检出19种基因型，高危亚型13种，占HPV 阳性57.89%，低危亚型6种占42.11%，高危亚型主要有HPVl6、58、52、33、18、6、45等13种。低危主要有HPV6、11、40、42、43、44等6种。47例CINⅠ、49例CINⅡ、38例CINⅢ及4例宫颈癌组织中HPV阳性率分别为63.4%、85.3%、92.1%、100%。CIN检出高危HPV基因型16、58、52、33、18等，4例宫颈癌组织中即检出HPV基因型HPV16、58、33。结论本辖区成年女性HPV感染率为19.7%，高危HPV感染率达11.3%。本地女性CIN及宫颈癌组织中高危HPV感染率较高，HPV16、58、52、33、18可能是本地区CIN及宫颈癌常见的高危HPV基因型。 |
| 英文摘要: |
| ObjectiveTo investigate human papilloma virus (HPV) infection and HPV genotype among the adult female in Huizhou city, in order to provide the best policy for cervical cancer screening and prevention. Methods From January 2009 to december 2011, we collected 5 860 cases of cervical cell specimens from department of gynecology in hospital.Among the cervical cell specimens , 47 cases of CIN Ⅰ，49 cases of CIN Ⅱ，38 cases of CIN Ⅲ，4 cases of cervical cancer were confirmed by pathology diagnosis，and nucleic acid molecular hybridization technique was adopted for Screening of HPV infection and HPV genotype in all of the cervical cell specimens . ResultsFor 5 680 cases of cervical cell specimens, the number of HPV-positive specimens were 1 154, with an infection rate of 19.7%. The female aged under 20 years , 20 to 30 years and 51 to 60 years had higher infection rate of 23.7%(22/93),20.22% (319/1 578)，22.8%（61/268）.19 species of genotype were detected in the specimens, including 13 species of high risk HPV（hrhpv） genotype and 6 species of low risk HPV(Lrhpv), the rate of hrhpv was 57.9% in the positive specimens, the main hrhpv genotype was hpv16，58，52，33，18 , et al. and the Lrhpv genotype was hpv6，11，40，43，44, et al .There were higher infection rates in CIN and cervical cancer, the hrHPV-positive rate in 47 cases of CINI，49 cases of CIN Ⅱ，38 cases of CIN Ⅲ, 4 cases of cervical cancer were 63.4%，85.3%，92.1%，100% respectively. The Lrhpv genotype in CIN were hpv 16，58，52，33，18,and Lrhpv 16，58，33 were found in 4 cases of cervical cancer. ConclusionThis study indicated the rate of HPV infection was 19.7% for adult female in Huihzou city. There was higher infection rate in CIN and cervical cancer. The main epidemic hrhpv genotype were HPV16，58，52，33，18 in this locality for CIN and cervical cancer. |
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