| 刘欢，马小峰，罗湘俊.瑞舒伐他汀对冠心病患者血清载脂蛋白A5水平的影响.[J].中南医学科学杂志.,2012,40(6):603-606. |
| 瑞舒伐他汀对冠心病患者血清载脂蛋白A5水平的影响 |
| Effect of Rosuvastatin on the Serum Level of Apolipoprotein A5 in Patients With Coronary Heart Disease |
| 投稿时间：2011-12-28 |
| DOI： |
| 中文关键词: 瑞舒伐他汀 载脂蛋白A5 血脂 |
| 英文关键词:Rosuvastatin Apolipoprotein A5 serum lipids |
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| 中文摘要: |
| 目的探讨瑞舒伐他汀对冠心病患者载脂蛋白A5（ApoA5）及血脂水平的影响，研究ApoA5与血脂谱之间的关系。方法将入选153例冠心病住院患者回顾性分为对照组75例与治疗组78例。对照组给予阿司匹林+氯吡格雷+β受体阻滞剂+ACEI，治疗组在对照组治疗基础上加用瑞舒伐他汀10 mg/天治疗8周，分别检测两组患者治疗前后血清ApoA5及甘油三酯（TG）、总胆固醇(TC)、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平。比较两组治疗前后的ApoA5和血脂水平，并分析ApoA5和血脂的相关性。结果ApoA5与TG呈负相关（r=-0.268,P<0.05），与TC、HDL-C和LDL-C无明显相关（P>0.05）。用药后治疗组ApoA5水平(369.6±28.76 ng/mL)明显高于对照组（195.83±20.10 ng/mL），差异有显著性（P<0.05）。结论瑞舒伐他汀能显著升高冠心病患者血清ApoA5水平，降低血清甘油三酯水平。 |
| 英文摘要: |
| ObjectiveTo explore the effect of rosuvastatin on the serum level of apolipoprotein A5（ApoA5） in patients with coronary heart disease,and to study the relationships between ApoA5 and serum lipids.Methods153 patients with coronary heart disease were randomized into two groups:control group(n=75),with treatment of aspirin,Clopidogrel,β-receptor blocker and ACEI;therapy group(n=78)，in addition to aspirin,Clopidogrel,β-receptor blocker and ACEI,treated with rosuvastatin for 8 weeks.The serum ApoA5 levels were measured by ELISA in both groups,while triglyceride (TG)，total cholesterol (TC)，high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were also measured.ResultsApoA5 was negatively correlated with TG（r=-0.268,P<0.05）,but no significant relationships were found between ApoA5 and TC，HDL-C and LDL-C.Compared with control group(195.83±20.10 ng/mL),serum ApoA5 level was significantly increased in therapy group(369.6±28.76 ng/mL)after treatment with rosuvastatin(P<0.05).ConclusionsRosuvastatin can significantly increase serum ApoA5 level,while reduce serum TG level. |
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