| 李玉珍，鲍蕴文，薛春玲，汪云霞，刘彩玲，李红玉，钟永根.118株肺炎链球菌的临床分布及耐药性分析.[J].中南医学科学杂志.,2012,40(6):575-577. |
| 118株肺炎链球菌的临床分布及耐药性分析 |
| Clinical Distribution and Antibiotic Resistance of 118 Strains of Streptococcus Pneumoniae |
| 投稿时间：2012-07-02 |
| DOI： |
| 中文关键词: 肺炎链球菌 临床分布 耐药性 |
| 英文关键词:Streptococcus Pneumoniae clinical distribution drug-resistance |
| 基金项目:河源市科技计划项目（编号：2012—018）资助. |
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| 中文摘要: |
| 目的了解肺炎链球菌的临床分布及耐药情况，为临床合理用药提供依据。方法浓度梯度法（E-test）检测青霉素和头孢噻肟的最低抑菌浓度（minimum inhibitory concentration,MIC），其他11种抗生素采用纸片扩散法进行药敏试验。结果共检出118株（118例）肺炎链球菌。标本来源以痰、眼分泌物、咽拭子为主，分别占50.8%、30.5%、16.1%；病区分布主要在儿科、眼科，分别为51.7%、30.5%。其对青霉素、头孢噻肟、万古霉素、奎奴普汀/达福普汀、利福平、利奈唑胺耐药率为0.0%；对左氧氟沙星、氧氟沙星和氯霉素耐药率分别为1.7%、1.7%和11.0%，对克林霉素、四环素、复方新诺明、红霉素耐药率均在80.0%以上。结论118株肺炎链球菌主要来自痰标本，分布在儿科。青霉素、头孢噻肟、万古霉素等抗生素对其有较好的体外抗菌活性。 |
| 英文摘要: |
| ObjectiveTo provide basis for clinical and reasonable use of medication by investigating distribution of Streptococcus Pneumoniae(SPN) and conditions of the drug resistance.MethodsConcentration gradient method (E-test) was used to detect minimum inhibitory concentration (MIC) of Penicillin and Cefotaxime,other 11 kinds of antibiotics were proceeded by disc-diffusion (K-B) method for Antibiotic Susceptibility Test (AST).Results118 strains of SPN were detected.The source of specimens were mainly from sputum,eye secretions and throat swab,accounting for 50.8%,30.5% and 16.1% respectively.The distribution were mainly in pediatric and ophthalmology,accounting for 51.7% and 30.5% respectively.Antimicrobial susceptibility test showed that the resistance rate of SPN to Penicillin,Cefotaxime,Vancomycin,Quinupristin-dalfopristin,Rifampin,Linezolid were 0.0%;to Levofloxacin,Ofloxacin and Chloramphenicol were 1.7%,1.7% and 11.0% respectively;to Clindamycin,Tetracycline,Trimethoprim-sulfamethoxazole,Erythromycin were higher than 80.0%.Conclusions118 strains SPN were mainly from sputum specimens,distributed in pediatric primarily.Penicillin,Cefotaxime,Vancomycin etc had better antimicrobial activity in vitro. |
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