| 李荣国，王剑，王小鸥，凌洪.高渗盐水治疗重型颅脑外伤后脑水肿疗效观察.[J].中南医学科学杂志.,2012,40(5):487-489. |
| 高渗盐水治疗重型颅脑外伤后脑水肿疗效观察 |
| Effects of 7.5% Hypertonic Saline on Brain Edema After Severe Traumatic Brain Injury |
| 投稿时间：2011-12-28 |
| DOI： |
| 中文关键词: 高渗盐 颅脑外伤 颅内压 脑灌注压 |
| 英文关键词:hypertonic saline brain injury intracranial pressure cerebral perfusion pressure |
| 基金项目: |
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| 中文摘要: |
| 目的回顾性观察7.5%高渗盐水对重型颅脑外伤后脑水肿患者降低颅内压，提高脑灌注压的效果。方法回顾性选择120例重型颅脑外伤患者，根据治疗方案将其分为高渗盐组和甘露醇组，每组各60例，持续监测患者平均动脉压、颅内压，比较两组之间颅内压降低，脑灌注压提高的效果。结果两组颅内压降低幅度无统计学差异(P>0.05)，但7.5%高渗盐组患者脑灌注压和平均动脉压明显高于甘露醇组(P<0.05)。结论7.5%高渗盐水在提高颅脑外伤后脑灌注压和平均动脉压方面有显著效果，是一种值得推广的颅脑外伤脱水降颅压药物。 |
| 英文摘要: |
| ObjectiveTo explore the effect of 7.5% hypertonic saline on brain edema in patients with severe head trauma，decreasing intracranial pressure and increasing cerebral perfusion pressure.Method120 patients were divided into two groups，60 cases in each group，with continuous monitoring of patients with mean arterial pressure，intracranial pressure，comparing each group to reduce intracranial pressure and enhance the effect of cerebral perfusion pressure.ResultIn 7.5% hypertonic saline group rate of cerebral perfusion pressure and rate of the average arterial pressure were significantly higher than the other group (P<0.05)，but with no significant statistic difference in the rate of intracranial pressure between them (P>0.05).Conclusions7.5% hypertonic saline in improving posttraumatic cerebral perfusion pressure and mean arterial pressure has a significant effect. It is worthy of popularization in craniocerebral trauma dehydration in reducing intracranial pressure drug. |
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