| 欧阳劭， 陈伟.氯沙坦钾对慢性心力衰竭患者尿液水通道蛋白2的影响.[J].中南医学科学杂志.,2012,40(5):484-486. |
| 氯沙坦钾对慢性心力衰竭患者尿液水通道蛋白2的影响 |
| Effects of Losartan Potassium on the Concentration of Urine Aquaporin-2 in Congestive Heart Failure Patient |
| 投稿时间：2011-12-09 |
| DOI： |
| 中文关键词: 心力衰竭 水通道蛋白2 血管加压素 氯沙坦钾 |
| 英文关键词:congestive heart failure aquaporin-2 plasma arginine vasopressin losartan potassium |
| 基金项目:衡阳市科技局资助项目（2011KS29）. |
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| 中文摘要: |
| 目的探讨氯沙坦钾对慢性心力衰竭患者尿液水通道蛋白2(AQP2)浓度的影响。方法慢性心力衰竭（CHF）患者203例，分为常规治疗组(100例)和氯沙坦钾组(103例)，另设正常对照组（50例），用放射免疫法检测血浆血管加压素（AVP）浓度、间接ELISA法检测尿液AQP2浓度，用药12周，治疗前后各1天采血检测血浆AVP浓度、留尿检测尿液AQP2浓度，比较其变化。结果与正常对照组比较，氯沙坦钾组治疗前后AVP和AQP2浓度均显著升高（P均＜0.05），常规治疗组治疗前后AVP和AQP2浓度均显著升高（P均＜0.05）。氯沙坦钾组治疗后AVP和AQP2浓度低于药物治疗前，也低于常规组治疗后（P均＜0.05）。结论CHF患者尿液AQP2排出增多，氯沙坦钾减少尿液AQP2排出，抑制集合管对水的重吸收，减轻水钠潴留，减轻心脏前负荷，延缓心力衰竭发展。 |
| 英文摘要: |
| ObjectiveTo investigate effects of losartan potassium on the concentration of urine aquaporin-2 (u-AQP2) in congestive heart failure patients.Methods203 patients with CHF were randomly divided into two groups： losartan potassium group (103 cases) and general treatment group (100 cases).These patients were compared against 50 normal control subjects.In all subjects，the concentration of plasma arginine vasopressin (p-AVP) were detected by radioimmunoassay (RIA)，the concentration of u-AQP2 were detected by indirect enzyme linked immunosorbent assay (indirect ELISA)，to analyse the relationship of u-AQP2 and p-AVP before and after 12 week treatment.ResultThe concentration of p-AVP and u-AQP2 in losartan potassium group and general treatment group were increased compared with normal control subjects before and after treatment（P<0.05）； the concentration of p-AVP and u-AQP2 in losartan potassium group were decreased after treatment（P<0.05），and were decreased compared with general treatment group after treatment（P<0.05）.ConclusionThe Losartan potassium downregulated renal AQP2 gene and protein expression，reduced the increased excretion of the u-AQP2 in CHF patients， reduced cardiac preload and delayed the development of CHF by blocking the water reabsorption in collecting duct. |
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