| 杨靖，钟警，陈亚军，肖新华 ， 文格波.抗甲状腺药物治疗8周内出现粒细胞缺乏患者13例临床分析.[J].中南医学科学杂志.,2012,40(5):477-479. |
| 抗甲状腺药物治疗8周内出现粒细胞缺乏患者13例临床分析 |
| Clinical Analysis of 13 Cases With Agranulocytosis Induced by Antithyroid Drugs Within 8 Weeks |
| 投稿时间：2012-03-05 |
| DOI： |
| 中文关键词: 粒细胞缺乏症 抗甲状腺药物 粒细胞集落刺激因子 |
| 英文关键词:agranulocytosis antithyroid drugs granulocyte colony-stimulating factor （G-CSF） |
| 基金项目:衡阳市科技计划项目（2011KJ33）. |
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| 中文摘要: |
| 目的分析抗甲状腺药物（ATD）治疗8周内出现粒细胞缺乏症患者的临床特点。方法对13例服用抗甲状腺药物8周内导致粒细胞缺乏的住院患者临床资料进行回顾性分析。结果13例粒缺患者中10例出现感染症状，其中呼吸系统感染8例。所有患者均接受了粒细胞集落刺激因子（G-CSF）治疗，其中12例患者接受G-CSF治疗24 h后中性粒细胞上升至1.0×109/L以上， 1 例患者1周后仍然粒细胞缺乏，最终因脓毒性休克死亡。结论ATD导致粒细胞缺乏的患者容易继发感染，以呼吸系统感染最为常见。接受G-CSF治疗24 h后中性粒细胞上升至1.0×109/L以上者预后良好。 |
| 英文摘要: |
| ObjectiveTo investigate the clinical features of agranulocytosis induced by antithyroid drugs （ATD）within 8 weeks after administration.MethodsThe clinical data of 13 antithyroid drug induced agranulocytosis patients in two affiliated hospitals were retrospectively analyzed.Results10 cases manifested infection symptoms such as fever， pharyngalgia， cough and so on. 8 patients showed infections of the respiratory system. All of them received subcutaneous injection of granulocyte colony- stimulating factor （G-CSF）. As a result， granulocytes count of 12 patients were restored to above 1.0×109/L 24 hours later. One patient died of septic shock for the sustained agranulocytosis even after repeated inject of G-CSF for 7 days.ConclusionThe peripheral leucocytes should be closely monitored during this period. Opportunistic infection is facilited to those patients， the most coummon infection place is respiratory tract . Patients with granulocytes increased to more than 1.0×109/L 24 hours after G-CSF treatment is usually in good prognosis. |
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