| 莫靓，雷正文，游咏，冯耀光.非小细胞肺癌中VEGF-C，VEGF-D及MMP-12的表达.[J].中南医学科学杂志.,2012,40(5):472-476. |
| 非小细胞肺癌中VEGF-C，VEGF-D及MMP-12的表达 |
| Expression of VEGF-C, VEGF-D and MMP-12 in Non-Small Cell Lung Cancer |
| 投稿时间：2012-04-09 |
| DOI： |
| 中文关键词: 血管内皮细胞生长因子 基质金属蛋白酶-12 非小细胞肺癌 纵隔淋巴结转移 |
| 英文关键词:VEGF MMP-12 NSCLC LNM |
| 基金项目:衡阳市科技发展计划项目（2009（KJ）38）. |
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| 中文摘要: |
| 目的对非小细胞肺癌（NSCLC）组织中血管内皮细胞生长因子C（VEGF-C）、VEGF-D及基质金属蛋白酶-12（MMP-12）的表达进行检测，探讨这3个因子与NSCLC纵隔淋巴结转移的相关性。方法采集60例NSCLC组织和癌旁组织，应用免疫组织化学方法检测其VEGF-C，VEGF-D及MMP-12的表达，并分析其与临床病理因素之间的相关性。结果VEGF-C，VEGF-D及MMP-12蛋白在NSCLC组织中呈高表达（96.7%、93.3%及91.7%），显著高于癌旁组织(P<0.01)。 VEGF-C，VEGF-D及MMP-12蛋白的表达在有淋巴结转移的病例显著高于没有转移的病例（χ2=13.237，χ2=6.960，χ2=9.870；P=0.000，P=0.008，P=0.002）。VEGF-C，VEGF-D及MMP-12蛋白表达与性别、年龄、分化程度以及组织学类型无关（χ2=0.472；P=0.244），但与病理TNM分期（PTNM）有关（P=0.01）。在有纵隔淋巴结转移的组织中，VEGF-C，VEGF-D与MMP-12蛋白表达均呈正相关（r＝0.850，P＝0.000；r＝0.787，P＝0.000；r＝0.914，P＝0.000）。结论VEGF-C，VEGF-D及MMP-12蛋白在有纵隔淋巴结转移NSCLC的高表达与其淋巴结转移密切相关，VEGF-C，VEGF-D及MMP-12蛋白有成为NSCLC治疗中新靶位点的潜在可能。 |
| 英文摘要: |
| ObjectiveThrough detecting the expressions of VEGF-C, VEGF-D and MMP-12 in the tissues of Non-small cell lung cancer and peritumoral, to investigate their correlations with lymph node metastasis of NSCLC．Methods Expressions of VEGF-C, VEGF-D and MMP-12 in 60 cases of tissues of Non-small cell lung cancer and peritumoral were detected by immunohistochemistry, and their correlations with clinical-pathological findings were analysed in patients．ResultsThe positive rates of VEGF-C，VEGF-D andMMP-12 were 96.7%％，93.3%，91.7% respectively，which were significantly higher than those of the tissues of peritumoral（P<0.01）．The expression of VEGF-C，VEGF-D and MMP-12 protein in lymph node metastasis was significantly higher than the cases without lymph node metastasis(χ2=13.237，χ2=6.960，χ2=9.870；P=0.000, P=0.000, P=0.000).The expressions of VEGF-C，VEGF-D and mmp-12 protein in NSCLC were not correlated with gender，age，degree of differentiation and histological types（χ2=0.472；P=0.244），but correlated significantly with PTNM stage（P=0．01）．Significant correlations between VEGF-C and VEGF-D（r＝0.929，P＝0.000），VEGF-C and MMP-12（r＝0.787，P＝0.000）,VEGF-D and MMP-12(r＝0.914，P＝0.000) expression were observed in LNM．ConclusionsThere was significant correlation between the high expression of VEGF-C，VEGF-D and MMP-12 and lymph node metastasis in tissues of NSCLC. |
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