| 杨红霞，蒋恒波，张蔚，莫世芳，莫龙.培哚普利联合缬沙坦对高血压合并糖尿病患者微量蛋白尿的影响.[J].中南医学科学杂志.,2012,40(4):381-383. |
| 培哚普利联合缬沙坦对高血压合并糖尿病患者微量蛋白尿的影响 |
| Combinative Treatment Effects of Perindopril and Valsartan on Microdose Proteinuria in Patients With the Combination of Hypertension and Diabetes Mellitns |
| 投稿时间：2012-03-05 |
| DOI： |
| 中文关键词: 培哚普利 缬沙坦 高血压 糖尿病 微量蛋白尿 |
| 英文关键词:perindopril valsartan hypertension diabetes mellitus microdose proteinuria |
| 基金项目: |
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| 中文摘要: |
| 目的通过观察培哚普利联合缬沙坦对高血压合并糖尿病患者蛋白尿的影响，来探讨培哚普利联合缬沙坦对肾脏的保护作用。方法将135例高血压合并糖尿病患者随机分为培哚普利组（培哚普利4 mg/天）、缬沙坦组（缬沙坦80 mg/天）和联合用药组(缬沙坦80 mg/天+培哚普利4 mg/天)。各组均治疗8周。观察治疗前后血清肌酐定量、24 h尿蛋白总量及血压的变化。结果治疗8周后，3组血清肌酐定量较治疗前稍有减低，但差异无统计学意义（P>0.05)；3组24 h尿蛋白总量、血压较治疗前明显降低（P<0.05)，联合用药组比培哚普利组或缬沙坦组下降更显著（P<0.05)，而培哚普利组与缬沙坦组间差异无统计学意义（P>0.05)。结论培哚普利联合缬沙坦能有效降低高血压合并糖尿病患者血压，减少蛋白尿，具有肾脏保护作用。 |
| 英文摘要: |
| ObjectiveTo investigate the renal protective effects of the combinative treatment of perindopril and valsartan in patients with the combination of hypertension and diabetes.MethodsA total of 200 patients with the combination of hypertension and diabetes mellitns were divided to three groups randomly.Perindopril group were treated with perindopril;Valsartan group were treated with valsartan;combinative treatment group were treated with both perindopril and valsartan.After 8 weeks，blood pressure，24 h-urine microdose protein and serum creatinine level were investigated.ResultsThe blood pressure level，24h-urine microdose protein of all three groups were lowered，and the changes in combinative treatment of perindopril and valsartan group were more significant(P<0.05).ConclusionCombinative treatment of perindopril and valsartan was more effective in decreasing microdose proteinuria and controlling blood pressure.Combinative treatment of perindopril and valsartan maybe have renal protection efficacy. |
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