| 贺军，丁成明，贺更生，黄秋林.ESM-1和MMP-3表达与肝癌侵袭转移的关系.[J].中南医学科学杂志.,2012,40(4):368-372. |
| ESM-1和MMP-3表达与肝癌侵袭转移的关系 |
| Relationship Between Expression of ESM-1 and MMP-3 and Invasion and Metastasis of Human Hepatocellular Carcinoma |
| 投稿时间：2012-03-05 |
| DOI： |
| 中文关键词: 肝细胞癌 内皮细胞特异性分子-1 基质金属蛋白酶-3 肿瘤侵袭转移 |
| 英文关键词:hepatocellular carcinoma endothelial cell specific molecule-1 matrix metalloproteinase -3 tumour invasion and metastasis |
| 基金项目:湖南省自然科学基金项目(11JJ3114). |
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| 中文摘要: |
| 目的探讨内皮细胞特异性分子-1(ESM-1)和基质金属蛋白酶-3(MMP-3)表达与肝细胞癌（HCC）侵袭转移的关系。方法应用免疫组织化学方法与图像分析系统检测ESM-1和MMP-3在40例HCC组织（实验组）及15例肝内胆管结石患者肝组织（对照组）的表达水平；分析HCC组织中ESM-1、MMP-3的表达与临床病理特征的关系及两者之间表达水平的相关性。结果ESM-1、MMP-3在HCC组织中均高水平表达，对照组未见阳性表达，实验组与对照组间表达差异均有显著性（P<0.05）；ESM-1在HCC组织中的表达与甲胎蛋白含量、肝硬化、肿瘤大小、分化程度、门静脉侵犯及TNM分期有关（P<0.05）；MMP-3在HCC组织中的表达与门静脉侵犯、HBV感染、肿瘤大小、分化程度及TNM分期有关（P<0.05）；ESM-1与MMP-3在HCC组织中的表达呈正相关(r=0.641，P<0.05)。结论检测ESM-1、MMP-3在HCC中的表达可能有助于对HCC侵袭和转移的评估。 |
| 英文摘要: |
| ObjectiveTo explore the relationship between expression of ESM-1 and MMP-3 and invasion and metastasis of human hepatocellular carcinoma (HCC).MethodsThe expression levels of ESM-1 and MMP-3 in 40 specimens with HCC (test group) and 15 specimens of liver tissue of intrahepatic bile duct stone (control group) were detected by immunohistochemistry and an image-analysis system. The relativity between the expression of ESM-1 and MMP-3 and clinicopathologic features and the correlation between the expression of ESM-1 and MMP-3 were analysed.ResultsESM-1,MMP-3were expressed at high level in all 40 specimens, but not expressed in liver tissues of 15 specimens with intrahepatic bile duct stone. There was significant difference of expression of ESM-1and MMP-3 between test group and control group (P<0.05).The expression of ESM-1 in HCC tissues was positively correlated with the level of preoperative serum alpha-fetoprotein (AFP), cirrhosis, tumor size, the histological differentiation, venous invasion and TNM stage (P<0.05). The expression of MMP-3 was positively correlated with the HBV infection, tumor size, venous invasion, histological differentiation and TNM stage (P<0.05). The mean gray scale of ESM-1 was positively correlated with that of MMP-3 (r＝0.641，P<0.05). ConclusionsESM-1 and MMP-3 may be used as the new useful predictors of invasion and metastasis in patients with HCC. |
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