| 陈永静，许翠萍，马峻杰.奥沙利铂联合5-FU和CF术前治疗直肠癌28例疗效观察.[J].中南医学科学杂志.,2012,40(3):287-290. |
| 奥沙利铂联合5-FU和CF术前治疗直肠癌28例疗效观察 |
| Evaluate the Effect of Preoperative Chemotherapy Oxaliplatin Combined With 5-FU and CF in 28 Patients of Rectal Cancer |
| 投稿时间：2012-03-22 |
| DOI： |
| 中文关键词: 直肠癌 奥沙利铂 5-氟尿嘧啶(5-FU) 亚叶酸钙（CF） 疗效评价 |
| 英文关键词:rectal cancer Oxaliplatin 5-FU Calcium Folinate efficacy evaluation |
| 基金项目: |
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| 中文摘要: |
| 目的观察奥沙利铂联合5-氟尿嘧啶(5-FU)、亚叶酸钙（CF）术前治疗直肠癌患者的疗效。方法 |
| 英文摘要: |
| ObjectiveTo evaluate the effect of preoperative chemotherapy in combination with Oxaliplatin,fluorouracil(5-FU) and Calcium Folinate（CF） in rectal cancer patients.Methods60 patients with rectal cancer were divided into combined chemotherapy group（28 cases）and simple chemotherapy group（32 cases）.The three drugs of Oxaliplatin,5-FU and CF were administrated to combined chemotherapy group and the drugs of 5-FU and CF were administrated to simple chemotherapy group before surgery.All patients were treated with three cycles of chemotherapy based on evaluation criteria of the solid tumors according to WHO criterion.Post-operative specimens dissipated by Wheeler Rectal Cancer Regression Grade.The mass tumor efficacy and rectal cancer regression were compared between the two groups.ResultsThe total effective rate of combined chemotherapy group was 64 %( 18 cases),and that in the simple chemotherapy group was 19% (6 cases),moreover,there was significant difference in two groups(P<0.05).the total effective rate of mass tumor regression in the combined chemotherapy group was 79%(22 cases),and that in the simple chemotherapy group was 34%(11 cases),the difference between the two groups was significant(P<0.05).ConclusionCombined treatment of Oxaliplatin with 5-FU,CF obviously reduced tumor mass and cancer cell regression than that of chemotherapy with 5-FU and CF. |
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