| 周高雅，胡治平.丁苯酞对急性缺血性脑卒中患者血清sICAM-1水平的影响及临床疗效观察.[J].中南医学科学杂志.,2012,40(3):260-262. |
| 丁苯酞对急性缺血性脑卒中患者血清sICAM-1水平的影响及临床疗效观察 |
| Effect of Dl-3-butylphthalide on the Expression of sICAM-1 Protein and the Neurological Function Improvement in Patients Subjected to Acute Ischemic Stroke |
| 投稿时间：2012-03-31 |
| DOI： |
| 中文关键词: 丁苯酚 急性缺血性脑卒中 sICAM-1 |
| 英文关键词:Dl-3-butylphthalide acute ischemic stroke sICAM-1 protein |
| 基金项目:国家自然科学基金（批准号81171239）资助，中南大学大学生创新性试验课题（YA08072）资助. |
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| 中文摘要: |
| 目的探讨急性缺血性脑卒中患者血清中sICAM-1表达水平的变化及丁苯酞胶囊的治疗作用。方法 |
| 英文摘要: |
| ObjectiveTo observe the effect of Dl-3-butylphthalide on the expression of sICAM-1 protein and the neurological function improvement in patients with acute ischemic stroke.MethodsAfter approved by the Central South University Committee on Ethics,119 cases of acute ischemic stroke were randomly divided into treatment group (61 cases treated with Dl-3-butylphthalide 200 mg tid po and routine therapy,totally 20 days) and control group (58 cases treated with routine therapy),40 health people were grouped into health group.The serum levels of sICAM-1 Protein were investigated before and 20 d after treatment,and NIHSS scores and clinical outcome were evaluated before and 20 d after treatment.ResultsAll patients showed obvious improvement after treatment.However the therapeutic efficacy of treatment group was significantly better than that of routine group (P<0.05).The serum levels of sICAM-1 protein of the treatment group was lower than that of the control group after 20 d (P<0.05).ConclusionOur research indicated that Dl-3-butylphthalide can reduce the injury of ischemic brain cells and improve therapeutic efficacy probably through down regulation of serum of sICAM-1 protein expression. |
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