| 戴小明，李彬鹏，黄秋林，贺更生，罗加兴.过氧化物酶体增殖物激活受体γ在HBV、HCV感染的肝细胞癌组织中表达的研究.[J].中南医学科学杂志.,2012,40(3):253-256. |
| 过氧化物酶体增殖物激活受体γ在HBV、HCV感染的肝细胞癌组织中表达的研究 |
| Studies on the Expression of Peroxisome Proliferator-activated Receptor γ(PPAR-γ)in Human Hepatocellula Carcinoma Between HBV-Related and HCV-Related Infections |
| 投稿时间：2012-03-05 |
| DOI： |
| 中文关键词: 肝细胞癌 PPAR-γ 免疫组织化学 HBV HCV |
| 英文关键词:HCC PPAR-γ Immunohistochemistry HBV HCV |
| 基金项目:衡阳市科技局课题（课题编号：2011KJ26）赞助. |
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| 中文摘要: |
| 目的探讨过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptor γ，PPAR-γ)在HBV、HCV感染的肝细胞癌（hepatocellula carcinoma HCC）组织及相应癌旁组织中的表达情况。方法收集经手术切除且有完整临床病理资料的40例HBV阳性及16例HCV阳性的HCC组织及相应癌旁组织标本，采用免疫组织化学法检测标本中PPAR-γ的表达，用图像分析系统测定PPAR-γ的灰度值并分析其与临床病理资料的关系。 |
| 英文摘要: |
| ObjectiveTo investigate the different expression of PPAR-γ in Human HCC tissues and the corresponding adjacent nontumoral liver tissues with HBV-Related and HCV-Related infections.MethodsCollect HCC tissues and the corresponding adjacent nontumoral liver tissues of 40 cases with HBV-Related infection,and 16 cases with HCV-Related infection,which were treated by surgical resection and had complete clinicopathological informations from October 2007 to October 2010.Detect the expression of PPAR-γ in the specimens by immunohistochemistry,make a quantitative analysis of the expression of PPAR-γ by accessing their mean gray scale with imaging analysis system,and then analyse the relationship between PPAR-γ and the clinicopathological informations.ResultsThe mean gray scale of HCC tissues and the corresponding adjacent nontumoral liver tissues between cases with HBV-Related infection and with HCV-Related infection were respectively 91.13±3.28 and 114.18±3.27,99.75±4.99 and 117.69±4.91,the differences between them are very significant(P<0.05).The expression degree of P PPAR-γ in HCC tissues was not associated with sex,age,tumor size,serum AFP levels,tumor embolus of portal vein or vena cana(P>0.05),but with differentiation grades and hepatitis virus infection(P<0.05).The differentiation grades between HCC tissues with HBV-Related infection and HCC tissues with HCV-Related infection have no significant difference(P>0.05).ConclusionsDetecting the expression of PPAR-γ may be valuable for evaluating malignancy extent.PPAR-γ may be a factor for which HCC with HBV-Related infection has a high incidence and a fast progress than HCC with HCV-Related infection. |
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