| 王琳，田绍文，黄伏连，Laudon Moshe，欧阳新平，周寿红.Neu-P11与褪黑素增强大鼠物体识别记忆.[J].中南医学科学杂志.,2012,40(3):223-226. |
| Neu-P11与褪黑素增强大鼠物体识别记忆 |
| Neu-P11 and Melatonin Enhance Memory Performance in the Object Recognition Task in Rats |
| 投稿时间：2010-11-24 |
| DOI： |
| 中文关键词: Neu-P11 褪黑素 物体识别 记忆 大鼠 |
| 英文关键词:Neu-P11 melatonin objective recognition memory rats |
| 基金项目:国家自然科学基金(30770689)资助；湖南省自然科学基金重点项目(10JJ2009)资助；湖南省教育厅一般项目(09C831)资助；以色列Neurim Pharmaceuticals公司研究基金资助. |
|
| 摘要点击次数: 892 |
| 全文下载次数: 1182 |
| 中文摘要: |
| 目的检测一种新颖的褪黑素受体激动剂Neu-P11与褪黑素对大鼠物体识别记忆的影响。方法 |
| 英文摘要: |
| ObjectiveTo investigate the effects of the novel melatonin agonist Neu-P11 and melatonin on memory performance in the objective recognition task in rats.MethodsThe behavioral procedure involved two phases:a 4-min training trial and a 3-min retention test trial.Neu-P11 (50 mg/kg),melatonin (50 mg/kg) and vehicle were injected 2 h before training phase in the morning or in the afternoon.The retention test was run 4 h or 24 h after training phase to assess the short-term and long-term memory performance,respectively.The total exploring time spent on the training phase and the discrimination index on the test phase was recorded.ResultsIn the short-term or the long-term memory task,there was no significant difference in the total time spent exploring between groups.Rats with Neu-P11 administrated both in the morning and in the afternoon showed more levels of the discrimination scores.Rats with melatonin administrated in the afternoon but not in the morning showed more levels of the discrimination scores.ConclusionNeu-P11 and melatonin enhance memory performance in the object recognition task in rats.Compared to melatonin,Neu-P11 exerts its effect with time-independent characters. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |