| 刘淑云，张平，蒋福生，曹琳，张新华.尼莫地平联合尼麦角林对缺血性脑卒中后认知功能的影响.[J].中南医学科学杂志.,2012,40(2):185-187. |
| 尼莫地平联合尼麦角林对缺血性脑卒中后认知功能的影响 |
| Nimodipine Combined With Nicergoline Treatment Ischemic Stroke Patinents With Vascular Cognitive Impairment |
| 投稿时间：2011-12-26 |
| DOI： |
| 中文关键词: 缺血性脑卒中 认知功能 尼莫地平 尼麦角林 |
| 英文关键词:ischemic stroke cognitive impairment nimodipine nicergoline |
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| 中文摘要: |
| 目的探讨尼莫地平联合尼麦角林对缺血性脑卒中患者早期认知功能损害的干预效果。方法回顾性分析116例缺血性脑卒中住院患者临床资料（常规治疗组57例，联合用药组59例）。常规治疗组采取常规缺血性脑卒中治疗方案，联合用药组在常规治疗组基础上加用尼莫地平以及尼麦角林。两组均采用蒙特利尔认知评估量表（北京版）在入院1周内及6个月后分别进行临床评估。结果6个月后量表评分常规治疗组远低于联合用药组(21.24±4.21比25.62±3.29，P<0.05)。常规治疗组6个月后评分低于入院时评分（21.24±4.21比25.09±4.64，P<0.05）。结论缺血性脑卒中后认知功能损害发生率高。尼麦角林联合尼莫地平早期干预能明显延缓缺血性脑卒中后认知功能损害的进展。 |
| 英文摘要: |
| ObjectiveTo study the therapeutic effect of nimodipine combined with nicergoline treatment Ischemic stroke patinents with vascular cognitive impairment.MethodsClinical data，116 subjects were randomly divided into conventional combined treatment group(57 patients) and combined treatment group of(59 patients),the conventional combined treatment group received conventional therapy,the combined treatment group received nimodipine and nicergoline.Montreal Cotive Assessment(MoCA) assessed in hospital and after 6 months.ResultsThe conventional combined treatment group MoCA scores were lower than the combined treatment group after 6 month(21.24±4.21 vs 25.62±3.29,P<0.05)；the conventional combined treatment group MoCA scores after 6 month were lower than before admission(21.24±4.21 vs 25.09±4.64，P<0.05).ConclusionsThere was a high occurrence rate of post-stroke cognitive impairment in Ischemic stroke.nimodipine combined with nicergoline can effectively reduce cognitive impairment of Ischemic stroke patinents. |
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