| 张济，刘罡，邹礼衡，颜家运.6-磷酸葡萄糖异构酶及抗CCP抗体等检测对类风湿关节炎的诊断价值.[J].中南医学科学杂志.,2012,40(1):79-82. |
| 6-磷酸葡萄糖异构酶及抗CCP抗体等检测对类风湿关节炎的诊断价值 |
| Diagnostic Significance of Rheumatoid Factor,Anti-cyclic Citrullinated Peptide Antibody and Anti-Sa Antibody in Patients With Rheumatoid Arthritis |
| 投稿时间：2011-09-26 |
| DOI： |
| 中文关键词: 抗CCP抗体 GPI 类风湿因子 类风湿关节炎 诊断 |
| 英文关键词:anti-cyclic citrullinated peptide glucose-6-phosphate isomerase rheumatoid factor rheumatoid arthritis diagnosis |
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| 中文摘要: |
| 目的探讨内镜逆行胰胆管造影(ERCP)在不明原因复发性胰腺炎诊治中的作用。方法本院2005年1月～2011年6月26例不明原因复发性胰腺炎患者，其中男10例，女16例，年龄31～85岁,中位年龄49岁,病程1～3年，发病次数2～4次。全部病例在急性发作期或发作间期均行磁共振下胰胆管造影（MRCP）及ERCP。结果26例患者行MRCP均未能明确诊断，经ERCP患者明确病因者12例（10例为胆管微结石，2例胰管开口狭窄并结石），可疑病因者14例（乳头旁憩室6例，十二指肠乳头炎8例）。并根据ERCP诊断结果24例行内镜下胆管乳头括约肌切开术(EST)，2例行胰管乳头括约肌切开术。26例患者术后随访1～2年胰腺炎未再复发，ERCP和EST过程中无胰腺炎加重、出血及穿孔等严重并发症发生。结论ERCP对不明原因复发性胰腺炎的临床诊断与治疗具有重要的作用。 |
| 英文摘要: |
| ObjectiveTo evaluate the clinical signification of rheumatoid factor (RF),anti-cyclic citrullinated peptide(CCP) antibody and glucose-6-phosphate isomerase(GPI).MethodsSera from 148 patients with RA,126 patients with autoimmune diseases and from 110 healthy control subjects were investigated by ELISA examining anti-CCP and GPI,rate nephelometry method measuring RF.The consistency of their clinical significance and efficiency in the diagnosis of RA were intercompared.ResultsIn RA patients,the mean seru concentration of CCP and GPI was higher than that in patients with autoimmune diseases and the healthy people(P<0.05).The specificity of CCP and GPI was higher than RF in the diagnosis of RA(P<0.05).In combination with 2 index or 3 index,the sensitivity of combination was lower,yet the specificity was higher(P<0.05).ConclusionAnti-CCP and GPI are sensitive and specific serological markers for RA,to associate result of anti-CCP and GPI with RF can be helpful for diagnosis of early RA and enhance the efficiency in diagnosis of RA. |
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