| 游咏，莫靓，桂庆军，尹凯，李熠，沈元琼.糖尿病对冠脉侧支循环的影响及与血清ADMA浓度的关系.[J].中南医学科学杂志.,2012,40(1):73-75. |
| 糖尿病对冠脉侧支循环的影响及与血清ADMA浓度的关系 |
| The Effects of Diabetes Mellitus on Coronary Collateral Circulation and Correlation With Serum Asymmetric Dimethylarginine |
| 投稿时间：2011-12-05 |
| DOI： |
| 中文关键词: 糖尿病 冠状动脉 侧支循环 ADMA |
| 英文关键词:diabetes mellitus coronary artery collateral circulation ADMA |
| 基金项目: |
|
| 摘要点击次数: 633 |
| 全文下载次数: 1371 |
| 中文摘要: |
| 目的进一步了解血浆置换治疗血栓性血小板减少性紫癜（TTP）的疗效。方法对4例确诊为TTP的患者给予糖皮质激素治疗联合血浆置换，深静脉置管建立体外循环，用贝朗Diapact CRRT机及费森尤斯P2S血浆分离器进行血浆置换，新鲜冰冻血浆为置换液，血浆置换量35～40 mL/kg，置换速度15～20 mL/min，血流速度120～150 mL/min，小剂量低分子肝素抗凝。血浆置换每日或隔日治疗1次。观察血液检验指标和临床症状改善情况。结果4例TTP患者每例完成3～5次血浆置换，治疗后血小板计数（PLT）、血红蛋白（Hb）上升，尿素（BUN）、总胆红素（IBIL）、乳酸脱氢酶（LDH）降低，治疗前后的结果经统计学处理，P<0.01,随访6个月全部治愈。 |
| 英文摘要: |
| ObjectiveTo investigate the effects of diabetes mellitus on coronary collateral circulation and the relationship between serum levels of ADMA and degrees of coronary collateral circulation in diabetes mellitus patients.Methods112 patients at least with the stenosis of one vessel >95% among coronary artery were consecutively enrolled.The 112 patients were divided into two groups:DM group and NDM group.Development of collaterals was classified by Rentrops method.The levels of ADMA were also determined.ResultsCompared with NDM group,poor CCC was higher in the DM group (P=0.043，P<0.05)，the serum ADMA concentration is also significantly higher than NDM group(P=0.000，P<0.01);Compared with NDM group in poorly developed collateral,the serum levels of ADMA in DM group were significantly increased (P=0.001，P<0.01).ConclusionsDiabetes mellitus inhibits the development of coronary collateral circulation in patients with severe coronary artery stenosis，which is related to the serum levels of ADMA. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |