| 周发平，袁秀琴，袁玉梅.衡阳市2002～2009年围生儿先天性唇腭裂畸形监测分析.[J].中南医学科学杂志.,2012,40(1):62-64. |
| 衡阳市2002～2009年围生儿先天性唇腭裂畸形监测分析 |
| Analysis on the Inborn Defect Data of Perinatal With Chilopalatognathus in the City of Hengyang from 2002 to 2009 |
| 投稿时间：2011-09-28 |
| DOI： |
| 中文关键词: 唇腭裂 出生缺陷监测 发病率 |
| 英文关键词:chilopalatognathus birth defects monitoring indidence rate |
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| 中文摘要: |
| 目的探讨丹红注射液对大鼠脑缺血再灌注损伤后TGF-β1表达的影响。方法选择健康成年SD大鼠（96只）为研究对象，随机分为正常对照组（8只）、假手术组（8只）、缺血再灌注组（40只）、药物干预组（40只），后两组根据不同再灌注时间点再分为6 h、24 h、48 h、72 h、7天共5个亚组，每个亚组8只。采用免疫组织化学方法检测大鼠脑组织中转化生长因子β1蛋白含量。结果缺血再灌注组、药物干预组各时间点组TGF-β1阳性细胞表达数均明显高于正常对照组和假手术组（P<0.05）；6 h时，药物干预组TGF-β1阳性细胞表达与缺血再灌注组差异无显著性（P>0.05），其余各时间点比较，药物干预组TGF-β1阳性细胞表达均明显高于缺血再灌注组（P<0.05）。丹红注射液干预后TGF-β1的表达上升，其中7天组表达明显高于其余各时间点干预组（P<0.05)。 |
| 英文摘要: |
| ObjectiveTo understand the incidence rate of inborn chilopalatognathus and its dynamic state changing for formulating a precaution of inborn chilopalatognathus.MethodsCollected and analyz the inborn defect data in hospital in the city of Hengyang from 2002 to 2009.ResultsThe average incidence rate of inborn chilopalatognathus was 15.19 in every ten thousand,the incidence rate of male was 17.51 in every ten thousand,the incidence rate of female was 9.57 in every ten thousand,the male-female incidence rate was 1.79 to 1(P=0.000),the difference between man and female was significant;the city incidence rate was 9.05 in every ten thousand,the country incidence rate was 17.89 in every ten thousands,there was a significance between them(P=0.000);the fourth quarter incidence rate was 25.32,9.24,9.63,19.32 in every ten thousand respectively,the fourth quarter incidence was significant（P=147.000，P=0.031）;the incidence rate in different age group pregnant woman was 65.81,15.22,12.96,9.51,56.29 in every ten thousand respectively,the difference between them was significant (P=0.000).ConclusionThe incidence rate of inborn chilopalatognathus during the 8 years in Hengyang city was rising;the country incidence rate was higher than citys;the incidence rate in winter and spring were higher than summer and autumns;the age of pregnant women lower than 20 and equal or higher than 35 was the high stage in the incidence rate of inborn chilopalatognathus. |
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