| 邓宇傲，谢宛玉，曹建国.黄荆子提取物对人卵巢癌CoC1细胞生长的影响.[J].中南医学科学杂志.,2011,39(6):637-639. |
| 黄荆子提取物对人卵巢癌CoC1细胞生长的影响 |
| Effect of the Extract of the Vitex Negundo Seed on the Growth of Human Ovarian Cancer CoC1 Cell Line |
| 投稿时间：2011-05-04 |
| DOI： |
| 中文关键词: 卵巢肿瘤 黄荆子 黄荆子乙酸乙酯提取物 |
| 英文关键词:ovarian cancer vitex negundo seed the acetoacetate extract of vitex negundo seed |
| 基金项目: |
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| 摘要点击次数: 1015 |
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| 中文摘要: |
| 目的观察4种黄荆子提取物（EVn-10、EVn-20、EVn-30、EVn-50）对人卵巢癌CoC1细胞生长的影响，筛选出抑制增殖活性最强的提取物。方法体外培养人卵巢癌CoC1细胞，分为4个实验组及3个对照组，以不同浓度的提取物及对照药物孵育48 h，MTT比色法测定四种提取物对人卵巢癌CoC1细胞增殖活性的影响。 |
| 英文摘要: |
| ObjectiveTo investigate the therapeutic effect of four species of extracts from Vitex negundo seed（EVn-10、EVn-20、EVn-30、EVn-50） on human ovarian cancer CoC1 cell line in vitro，thus to get the most effective one.MethodsCoC1 cells that cultured in vitro were divided into four experimental groups(EG) and three control groups(CG);Cells were treated with different concentrations extract in EG and CG done with control drug;The viability of CoC1 cells was determinated by MTT assay.ResultsFour species of extracts of Vitex negundo seed all inhibited viability of CoC1 cells.The acetoacetate extract of Vitex negundo seed(EVn-50) was the strongest in those,and its IC50 value was 1.02μg/mL.It was near to DDP（IC50 value was 0.82μg/mL）.ConclusionsThe acetoacetate extract of Vitex negundo seed(EVn-50) can inhibit viability and growth of human ovarian cancer CoC1 cell line. |
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