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全小青，张志伟，汤国辉，刘重元，吴勇军，贺修胜.组织芯片检测磷酸化AKT蛋白在不同胃组织中的表达.[J].中南医学科学杂志.,2011,39(6):634-636.

组织芯片检测磷酸化AKT蛋白在不同胃组织中的表达

Expression of Phosphorylation AKT Protein in Different Gastric Tissue Detected by Tissue Array

投稿时间：2011-07-21

DOI：

英文关键词:gastric carcinoma phosphorylation AKT protein tissue array

基金项目:

作者	单位
全小青¹，张志伟²，汤国辉³，刘重元²，吴勇军⁴，贺修胜²	1.南华大学医务所，湖南衡阳 421001；2.南华大学医学院肿瘤研究所肿瘤细胞与分子病理学湖南省高校重点实验室；3.南华大学附属南华医院肛肠科；4.湘潭市第一人民医院病理科

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中文摘要:

目的探讨磷酸化AKT蛋白在不同胃组织中的表达意义。方法采用免疫组织化学染色，检测胃组织芯片（包括对照组正常胃黏膜、癌旁、非典型增生、原发癌及淋巴结转移癌组织）中磷酸化AKT蛋白表达。结果与正常胃黏膜、癌旁和非典型增生组织相比，AKT蛋白磷酸化在原发癌、淋巴结转移癌中表达升高（P<0.01）；与正常胃黏膜组织比较，磷酸化AKT蛋白在非典型增生组织中表达上调（P=0.26）。结论磷酸化AKT蛋白表达与胃癌的发生发展有关。

英文摘要:

ObjectiveThis study aimed to investigate the expression of phosphorylation AKT protein in progress of occurrence and development of gastric carcinoma.MethodsThe phosphorylation AKT protein was analyzed by immunohistochemistry in gastric tissue array including normal gastric mucosa,peficancerous tissue,atypical hyperplasia tissue,primary cancer tissue and lymphonode metastatic carcinoma tissue.ResultsCompared with normal gastric mucosa,carcinoma side tissue and atypical hyperplasia tissue,the phosphorylation AKT protein was over-expression in primary cancer and lymphonode metastatic carcinoma (P<0.01).Compared with normal gastric mucosa,the expressed of phosphorylation AKT protein was up-regulated in atypical hyperplasia gastric tissue (P=0.26).ConclusionThe phosphorylation AKT protein was related with occurrence and development of gastric carcinoma.

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