| 王艳.白内障超声乳化术后应用激素和非甾体类抗炎药的临床疗效评价.[J].中南医学科学杂志.,2011,39(5):563-565. |
| 白内障超声乳化术后应用激素和非甾体类抗炎药的临床疗效评价 |
| Clinical Efficacy of Application of Glucocorticoid Combined With Nonsteroid Anti-inflammatory Drugs After Phacoemulsification |
| 投稿时间：2011-05-25 |
| DOI： |
| 中文关键词: 白内障 非甾体类抗炎药 激素类抗炎药 超声乳化 |
| 英文关键词:cataract nonsteroid anti-inflammatory drugs steroid anti-inflammatory drugs phacoemulsification |
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| 中文摘要: |
| 目的评价联用糖皮质激素（典必殊滴眼液）与非甾体抗炎药（普南扑灵滴眼液）对超声乳化白内障吸除植入人工晶体术后炎症反应的治疗效果，探讨控制白内障术后炎症的方法。方法将153例单纯性白内障患者随机分为3组，进行小切口超声乳化白内障吸除联合人工晶体植入术，术后使用滴眼液。典必殊组：单用典必殊液四周；普南扑灵组：单用普南扑灵四周；联合用药组：先联用典必殊和普南扑灵一周，后三周单用普南扑灵。3组在术后不同时间观察症状、体征并进行综合评分，测量房水闪辉和眼压。结果术后第3天、第7天时联合用药组综合评分明显低于两单用药组(P<0.05)，术后第3天、第7天、第14天和第30天时联合用药组房水闪辉值均明显减少于两单用药组(P<0.05)。与术前比，典必殊组术后第14、第30天眼压增加（P<0.05），普南扑灵组和联合用药组间眼压则无明显变化（P>0.05）。结论白内障术后联用典必殊和普南扑灵后再单用普南扑灵比单用典必殊或普南扑灵抗炎效果好，是减少术后炎症反应和避免眼压升高的较理想治疗方案。 |
| 英文摘要: |
| ObjectiveTo assess efficacy of glucocorticoid (Tobradex eyedrops) combined with NSAIDs (Pranopulin eyedrops) for treatment of ocular inflammation after ultrasonic phacoemulsification and intraocular lens ( IOL) implantation for investigation of control of inflammation after phacoemulsification.Methods153 patients with simple cataract were divided randomly into three groups.After phacoemulsification and IOL implantation,the patients were randomised to topical treatment with Tobradex eyedrops (Tobradex group) or Pranopulin eyedrops (Pranopulin group) for 4 weeks or Tobradex combined with Pranopulin for one week,then Pranopulin for 3 weeks (combination group).Symptoms and signs were observed for comprehensive assessment,and aqueous flare and intraocular pressure were measured.ResultsThe values of comprehensive assessment of combination group were significantly lower than that of Tobradex group and Pranopulin group at day 3 and day 7 post operation (P<0.05).The values of aqueous flare of combination group were significantly lower than that of Tobradex group and Pranopulin group at day 3,7,14 and 30 (P<0.05 ).There was a significant increase of intraocular pressure at day 14 or day 30 compared to preoperation in Tobradex group,but no significant changes of intraocular pressure were observed in Pranopulin group and combination group.ConclusionsCombined application of Tobradex with Pranopulin and following single application of Pranopulin shows better anti-inflammatory effect than single application of Tobradex or Pranopulin,which may be a therapeutic regimen for reducing postoperative inflammatory response and avoiding additional increase in intraocular pressure. |
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