| 李艳雯，谢小平，黎宇，刘双全，任林.279例儿童下呼吸道感染病原菌分布及耐药性分析.[J].中南医学科学杂志.,2011,39(5):544-546. |
| 279例儿童下呼吸道感染病原菌分布及耐药性分析 |
| Pathogen Distribution and Antibiotic Resistance in 279 Children With Lower Respiratory Tract Infection |
| 投稿时间：2011-04-19 |
| DOI： |
| 中文关键词: 痰培养 病原菌 耐药性 儿童 |
| 英文关键词:lower respiratory tract infection pathogens resistance children |
| 基金项目: |
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| 中文摘要: |
| 目的了解儿童呼吸道感染患者的病原学特点及病原菌耐药情况，指导临床合理用药。方法 |
| 英文摘要: |
| ObjectiveTo investigate the pathogenic change in children with lower respiratory tract infection (RTI) and to provide reference for clinical treatment.MethodsRetrospective analysis was conducted on sputum culti-vation results of RTI children who were hospitalized from January 2008 to December 2010.Results279 strains were isolated from 935 samples,positive rate was about 29.8%.Gram-positive microorganisms accounted for 22.9%(64)of the positive culture results,Gram-negative microorganisms accounted for 67.7% (189),and fungi accounted for 9.3%(26).The main pathogens were Escherichia coli,Klebsiella pneumoniae，Staphylococcus aureus and Streptococcus pneumoniae.The sensitive drugs of Gram-positive microorganisms were vancomycin,rifampicin,teicoplanin and minocyline.While the sensitive drugs of Gram-negative microorganisms were Meropenem imipenem,and amikacin.The drug resistance rate was increasing and some bacteria were multi drug resistance strains.ConclusionGram-negative bacilli are still the primary pathogens resulting in lower respiratory tract infection in children.Fungi and muti-drug-resistant bacteria are on the rise trend.In order to reduce drug resistance strains，it is important that bacterial culture should be carried out actively and antibiotics administration must be based on the drug sensitivity test of clinical significance. |
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