| 刘海英，邓晖.衡阳地区新生儿感染性肺炎病原菌分布及耐药分析.[J].中南医学科学杂志.,2011,39(4):416-418. |
| 衡阳地区新生儿感染性肺炎病原菌分布及耐药分析 |
| The Analysis of Distribution and Drug Resistance of Infectious Pneumonia in Neonates in Hengyang |
| 投稿时间：2011-05-24 |
| DOI： |
| 中文关键词: 感染性肺炎 病原菌 耐药性 新生儿 |
| 英文关键词:infectious pneumonia pathogens resistance newborn |
| 基金项目: |
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| 中文摘要: |
| 目的探讨衡阳地区新生儿感染性肺炎常见病原菌的种类及耐药情况，为临床合理用药提供理论依据。方法对本院新生儿科2007年04月～2011年03月收治的本地区583例感染性肺炎患儿的痰培养阳性结果及药敏结果进行回顾性统计分析。结果共分离出菌株371株,阳性率为63.6%，其中革兰阴性菌(G-)285株,占76.8%；革兰阳性菌(G+) 71株,占19.1%；真菌15株，占4.0%。病原菌主要为大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌、金黄色葡萄球菌、阴沟肠杆菌。革兰阴性菌对第二、三代头孢类抗生素耐药性高，但对碳青霉烯类和氨基糖苷类、喹诺酮类抗生素敏感性高；革兰阳性菌对克林霉素、β-内酰胺类抗生素耐药性高，而对万古霉素、利奈唑胺未见耐药。结论革兰阴性菌是衡阳地区新生儿感染性肺炎的主要病原菌，且耐药率高，临床应合理使用抗生素，延缓耐药性产生。 |
| 英文摘要: |
| ObjectiveTo explore the types and drug resistance of common pathogens of neonatal infectious pneumonia in Hengyang and provide a theoretical basis for rational drug use.MethodsWe retrospectively analyzed positive sputum culture and drug susceptibility results of 583 cases pneumonia in neonates of our hospital from April 2007 to March 2011.ResultsA total of 371 strains were isolated,the positive rate was 63.6%,Gram-negative (G-) bacteria 285,accounting for 76.8%;Gram-positive (G+) bacteria 71,accounting for 19.1%;15 strains of fungi,accounting for 4.0%.The main pathogens were Escherichia coli,Klebsiella pneumoniae,Pseudomonas aeruginosa,Staphylococcus aureus,Enterobacter cloacae.Gram-negative bacteria had high resistance in the second and third generation cephalosporins,while had high sensitivity to carbapenems and aminoglycosides,quinolones;Gram-positive bacteria had high resistance in clindamycin,β-lactam antibiotic,while with no resistance to vancomycin,linezolid.ConclusionGram-negative bacteria was major pathogens of infectious pneumonia in newborns in Hengyang and has a high resistance,so it should be used reasonably to delay the drug resistance. |
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