| 杨玉凤，邓海峰，田绍文.腹内侧前额叶注射β淀粉样多肽对大鼠自发活动的影响.[J].中南医学科学杂志.,2011,39(3):250-252. |
| 腹内侧前额叶注射β淀粉样多肽对大鼠自发活动的影响 |
| The Injection of β-amyloid into Ventronl Medial Prefrontal Cortex Impacts on Locomotor Activity in Rats |
| 投稿时间：2011-02-22 |
| DOI： |
| 中文关键词: 腹内侧前额叶 β淀粉样多肽 自发活动 大鼠 |
| 英文关键词:ventronl medial prefrontal cortex β-amyloid locomotor activity rat |
| 基金项目:国家自然科学基金(30770689)、湖南省自然科学基金重点项目(10JJ2009). |
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| 中文摘要: |
| 目的检测腹内侧前额叶微注射β淀粉样多肽对大鼠自发活动的影响。方法双侧腹内侧前额叶边缘下皮层区（IL区）微量注射Aβ1-42作为Aβ组，微注射溶媒为溶媒组，27天后进行自发活动检测，腹内侧前额叶进行石蜡切片HE染色。结果虽然HE染色显示Aβ组IL区细胞受损或完全消失，但Aβ组和溶媒组在大鼠自发活动的总路程、总时间、中间区域活动路程和中间区域活动时间等方面比较，差异均无显著性。结论腹内侧前额叶边缘下皮层区微注射β淀粉样多肽不影响大鼠本身的自发活动。 |
| 英文摘要: |
| ObjectiveTo assess the effects of the injection of β-amyloid into ventronl medial prefrontal cortex on locomotor activity in rats.MethodsAβ1-42 was injected into infralimibic cortex of ventronl medial prefrontal cortex in Aβgroup,and 6 μg vehicle was also injected into the identical cortex in contronl cortex.The locomotor activity was examined 27days after the administration.The sections were stained with haematoxylin-eosin(HE).ResultsCompared with vehicle group,though HE-staining showed neuronal loss around the injection site,the Aβgroup had no effect on the locomotor activity.ConclusionThe injection of β-amyloid into ventronl medial prefrontal cortex had no effect on locomotor activity in rats. |
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