| 王建平，李晶，邓珊珊，孙蓉，呙劲松，郑薇，董晨珊，黄干，周智广.衡阳地区初诊2型糖尿病患者谷氨酸脱羧酶抗体筛查.[J].中南医学科学杂志.,2011,39(2):170-172. |
| 衡阳地区初诊2型糖尿病患者谷氨酸脱羧酶抗体筛查 |
| Screening of GADA in Newly Diagnosed Type 2 Diabetic Patients in Hengyang Area |
| 投稿时间：2010-10-15 |
| DOI： |
| 中文关键词: 2型糖尿病 成人隐匿性自身免疫性糖尿病 谷氨酸脱羧酶抗体 |
| 英文关键词:T2DM LADA GADA |
| 基金项目:湖南省教育厅资助（09C844）. |
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| 中文摘要: |
| 目的探讨衡阳地区初诊2型糖尿病（T2DM）患者中成人隐匿性自身免疫性糖尿病（LADA）的患病率及其临床特征。方法对102例病程1年以内非酮症起病的初诊T2DM患者采用放射配体法检测谷氨酸脱羧酶抗体（GADA），同时测量身高、体重、体质指数（BMI）、血压，检测空腹血糖、空腹C肽（FCP）、糖化血红蛋白（HbA1c）、血脂、超敏促甲状腺激素（uTSH）、甲状腺球蛋白抗体（TG-Ab）与甲状腺过氧化物酶抗体（TPOAb），比较GADA阳性患者与GADA阴性患者之间的临床特征与生化特征差异。结果初诊T2DM患者GADA阳性率即LADA患病率为9.8%（10/102）；与GADA阴性患者比较，GADA阳性LADA患者BMI较小，空腹C肽水平较低，uTSH异常检出率与TPOAb阳性率增高（均P<0.05）。结论衡阳地区初诊2型糖尿病患者中存在一定比例的LADA患者；对于BMI较小、胰岛功能较差的初发T2DM患者应及早检测GADA。 |
| 英文摘要: |
| ObjectiveTo investigate prevalence and clinical feature in newly diagnosed type 2 diabetic(T2DM) patients in Hengyang area.Methods102 newly diagnosed type 2 diabetic patients whose course of disease within one year and without ketosis were measured glutaminic acid decarboxylase antibodies(GADA)by radioligand binding assay.At the same time,Ht,Wt,BMI,BP,FBG,FCP,HbA1c，TG,TC,HDLC,LDLC,uTSH,TG-Ab and TPO-Ab were measured,and the clinical and biochemistry difference between the GADA positive patients and GADA negative ones were compared.ResultsThe positive rate of GADA in patients with T2DM was 9.8%;Compared with GADA negative patients,BMI and FCP level was lower in patients of LADA with GADA positive,but the uTSH abnormal rate and the positive rate of TPO-Ab were higher(P<0.05).ConclusionsThere is certain proportion LADA patients in newly diagnosed type 2 diabetic patients in Hengyang area.The patient who possess a lower BMI,faintish function of pancreatic islet and suffering T2DM for first time should exam the GADA as soon as possible. |
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