| 曹玉梅.宫颈癌Ⅰb2-Ⅱb期术前全身新辅助化疗的疗效观察.[J].中南医学科学杂志.,2011,39(1):86-88. |
| 宫颈癌Ⅰb2-Ⅱb期术前全身新辅助化疗的疗效观察 |
| The Therapeutic Valve of Preoperative Neoadjuvant Chemotherapy for in Patient With Stage Ⅰb2-Ⅱb Bulky Cervical Cancer |
| 投稿时间：2010-09-02 |
| DOI： |
| 中文关键词: 术前全身新辅助化疗 宫颈癌 疗效 |
| 英文关键词:neoadjuvant chemotherapy cervical cancer effects |
| 基金项目: |
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| 中文摘要: |
| 目的探讨术前全身新辅助化疗（NACT）对Ⅰb2-Ⅱb期宫颈癌的疗效。方法观察组初治宫颈癌患者49例，均行病理确诊并采用PT方案（顺铂50 mg/m2+紫杉醇135～175 mg/m2）静脉化疗1～2疗程，化疗后15～20天行子宫广泛切除+盆腔淋巴结清扫术。同期手术并术中双侧髂内动脉灌注化疗（顺铂50 mg/m2）+术后紫杉醇135～175 mg/m2静脉化疗35例为对照组。在化疗有效率、术后病理及生存率等方面进行分析对比。 |
| 英文摘要: |
| ObjectiveTo explore the effect of preoperative neoadjuvant chemotherapy(NACT)on Ⅰb2-Ⅱb bulky cervical cancer.MethodsFrom December 2000 to December 2009 in Shaoyang City Hospital 49 initially treated patients underwent cervical disease and the correct PT program(cisplatin 50 mg/m2+ paclitaxel 135～175 mg/m2)intravenous chemotherapy for 1～2 courses of chemotherapy,15～20 days later radical resection of the uterus and pelvic lymph node dissection were conducted for the observation group.35 cases with surgery at the same period in the bilateral internal iliac arterial infusion chemotherapy(cisplatin 50 mg/m2)+ After intravenous chemotherapy paclitaxel 135～175 mg/m2 were used as the control group and the survival rate and pathological aspects were compared.ResultsThe overal response rate was 77.6%,the postoperative rate of cervical deep myometrial invasion，parametrial infiltration rate，pelvic lymph node metastasis rate of vaginal margin rate was statistically significant(P<0.05);operative time and blood loss compared with no difference in operative time，observed blood loss was significantly lower than the control group，which difference was statistically significant(P<0.05);neoadjuvant chemotherapy responders parametrial invasion and pelvic lymph node metastasis had lower response rate than those without，the difference was significant(P<0.05);and there was no cancer cell remained after operation，the 5-years survival rate of the two groups was 77.50% and 72.75%.There was no significant contrast between the two(P>0.05).ConclusionsNeoadjuvant Chemotherapy is a new and effective method for treatment of stage Ⅰb2-Ⅱb bulky cervical cancer.It shows promising prospect in clinical application. |
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