| 眭文妍,陈春燕,罗招阳,李维.PARP-1和Caspase-3在乳腺癌组织中的表达及临床意义.[J].中南医学科学杂志.,2010,(2):. |
| PARP-1和Caspase-3在乳腺癌组织中的表达及临床意义 |
| The Expression of PAPR-1 and Caspase-3 in Human Breast Cancer and Their Clinical Significance |
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| DOI： |
| 中文关键词: 乳腺癌 PARP-1 Caspase-3 免疫组化 |
| 英文关键词:PARP-1 Caspase-3 |
| 基金项目: |
| 眭文妍 陈春燕 罗招阳 李维 |
| 南华大学肿瘤研究所; |
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| 中文摘要: |
| 目的研究聚ADP核糖聚合酶-1(PARP-1)和Caspase-3在乳腺癌中的表达及其与临床特征的关系。方法采用免疫组化技术,检测277例乳腺癌和11例乳腺正常组织石蜡包埋标本中PARP-1及Caspase-3的表达,分析正常乳腺与乳腺癌组织中两者表达与临床参数的相关性,以及两者间的相关性。结果在277例乳腺癌组织中,PARP-1阳性表达率(62.09%,182/277)显著高于正常乳腺组织(27.27%,3/11)(P=0.009)。乳腺癌中有淋巴结转移者PARP-1阳性表达率(76.47%,130/170)高于无淋巴结转移者(48.59%,52/107),表明PARP-1与淋巴结转移相关(r=-0.286,P<0.001)。同时PARP-1在乳腺癌中的表达与组织学分级相关(r=0.018,P=0.002)。Caspase-3在正常乳腺组织的阳性表达率(72.73%,8/11)高于乳腺癌(42.24%,117/277)(P=0.046)。Caspase-3与PARP-1的表达在乳腺癌组织中呈负相关(r=-0.722,P<0.001)。结论PARP-1表达上调可能与乳腺癌的恶性生物学行为有关,Caspase-... |
| 英文摘要: |
| Objective To investigate the expressions of PARP-1 and Caspase-3 in normal breast tissues and breast cancer,and their relationships with the clinical features. Methods PARP-1 and Caspase-3 expressions were determined immunohistochemically on paraffin-embedded specimens of 277 breast cancer and 11 breast normal tissues.Relationships between expressions of PARP-1 and Caspase-3 and among the clinical features of breast normal tissues and breast cancer,as well as the relevance of PARP-1 and Caspase-3 in these t... |
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