| 罗永姣,刘红英.病毒性心肌炎患儿的T细胞免疫改变.[J].中南医学科学杂志.,2010,(1):. |
| 病毒性心肌炎患儿的T细胞免疫改变 |
| Study on the Dynamic Changes of T Lymphocyte Subsets in Children With Viral Myocarditis |
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| DOI： |
| 中文关键词: 病毒性心肌炎 T细胞亚群 自身免疫 |
| 英文关键词:viral myocarditis T lymphocyte subsets autoimmunity |
| 基金项目: |
| 罗永姣 刘红英 |
| 南华大学第一附属医院儿科; |
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| 中文摘要: |
| 目的探讨病毒性心肌炎患儿细胞免疫功能的动态变化规律。方法通过流式细胞技术,检测56例病毒性心肌炎患儿的急性期及恢复期血清中总T淋巴细胞(CD3)、T辅助细胞(CD4)和T抑制细胞(CD8)的水平进行分析,并与正常对照组比较。结果急性期CD3、CD4和CD8均下降,CD4/CD8降低;恢复期CD3及CD4均已恢复正常,仅CD8恢复较慢,仍略低于正常。结果提示病毒性心肌炎急性期细胞免疫功能低下,恢复期多数患儿免疫系统紊乱消失。结论检测外周血T淋巴细胞亚群表达对评估病毒性心肌炎患儿的免疫功能状况、疾病的诊断及病情严重度判断都具有重要的临床意义。 |
| 英文摘要: |
| Objective To explore the dynamic changes of T cellular immune function in children with viral myocarditis. Methods By using the flow cytometry,the antigens of CD3,CD4,CD8 on T lymphocytes in peripheral blood of 56 subjects diagnosed with viral myocarditis were examined respectively during acute stage and convalescent period.The obtained results were finally compared with those of other healthy children. Results During acute stage,the percentages of CD3 and CD4 and CD8 lymphocyte in peripheral blood decrease... |
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