| 贺栋梁,李小玲,蒋湘莲,李东阳.共轭亚油酸对铅脂质过氧化损伤的保护作用.[J].中南医学科学杂志.,2008,(4):. |
| 共轭亚油酸对铅脂质过氧化损伤的保护作用 |
| Effects of Conjugated Linoleic Acid Against Lipid Peroxidative Injury Induced by Lead on Mice |
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| DOI： |
| 中文关键词: 共轭亚油酸 铅 氧化损伤 |
| 英文关键词:CLA lead oxidative damage |
| 基金项目: |
| 贺栋梁 李小玲 蒋湘莲 李东阳 |
| 南华大学公共卫生学院,湖南衡阳421001 |
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| 中文摘要: |
| 目的 探讨共轭亚油酸(CLA)对铅致小鼠脂质过氧化损伤的保护作用.方法 50只昆明种健康成年小鼠随机等分为正常对照组、醋酸铅组(100 mg/kg)和3个CLA保护组(50 mg/kg,100 mg/kg,200 mg/kg),保护组采用铅和共轭亚油酸共同灌胃,各动物按体重0.1 mL/10g计算灌胃体积,隔日灌胃一次,共4周.检测小鼠心、脑和肝脏脏器系数及血清、肝组织中MDA含量及SOD、GSH-Px活性.结果 铅染毒组小鼠脏器系数增大(P<0.05),SOD和GSH-PX活性下降(P<0.05),MDA含量升高(P<0.05).中、高剂量CLA保护组小鼠脏器系数、SOD和GSH-PX活性以及MDA含量与铅损伤组比较,差异有显著性(P<0.05).结论 CLA对铅所致氧化损伤有保护作用. |
| 英文摘要: |
| Objective To explore effects of conjugeted linoleic acid(CLA) against lipid peroxidization induced by lead on mice. Methods 50 mice were averagely divided into five groups randomly.The organ coefficient of heart,liver and brain were calculated,and the activity of SOD,GSH-Px and content of MDA were measured by relative test. Results The content of MDA and activity of SOD,GSHPx in mouse blood serum and liver treated with CLA were coincident to the mice bearing lead(P<0.05),while the activity of SOD and GSH-PX... |
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