王堃,罗祎敏.生化标志物与绝经后妇女冠心病发生的相关性研究.[J].中南医学科学杂志.,2008,(3):.
生化标志物与绝经后妇女冠心病发生的相关性研究
The Relationship of Biomarkers and Coronary Heart Disease in Post-menopausal Women
  
DOI:
中文关键词:  C反应蛋白  冠心病  绝经  血清雌二醇  血脂
英文关键词:C-reactive Protein  Coronary heart disease  post-menopausa  E2  blood lipid  
基金项目:
王堃  罗祎敏
[1]衡阳市第三人民医院,湖南衡阳421001 [2]南华大学肿瘤研究所,湖南衡阳421001
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中文摘要:
      目的 研究血清中C反应蛋白(C-Reactive Protein,CRP)与绝经后妇女冠心病(coronary heart disease,CHD)之间的关系,并探讨甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)以及雌二醇(E2)等生化标志物与绝经后妇女冠心病发生的相关性.方法 选取115例绝经后女性住院病人为研究对象,排除其他与CRP升高相关疾病后分为冠心病组和非冠心病组.受检者于清晨空腹卧位抽取肘静脉血,分析TG、TC、HDL-C、LDL-C,同时测定了CRP和E2含量,分析他们与绝经后妇女冠心病之间的关系.结果 冠心病组血清CRP水平(6.01±2.58 mg/L)显著高于非冠心病组(1.69±0.93 mg/L);冠心病组TG水平明显高于非冠心病组,但两组,TC、HDL-C、LDL-C水平比较,差异均无显著性;冠心病组E2水平低于非冠心病组,差异有显著性.结论 血清CRF水平的升高可作为预测绝经后妇女冠心病发生的独立危险因素,而它与血脂、血清雌二醇之间无明显相关性;血清雌二醇与绝经后女性冠心病的发病有明显的关系.
英文摘要:
      Objective To study the correlation between the level of CRP and CHD of post-menopausal women,and TG,TC,HDL-C,LDL-C,CRP and E2 in the CHD development of post-menopausal women.Methods 115 cases of post-menopausal hospital patients,aged from 49-73 years old,were selected and the other diseases which can result in the raise of CRP were excluded.They were divided into 2 groups,CHD group and non-CHD group.Then their ulnar vein blood samples were drawn under supine position and limosis condition.Routine biochemica...
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