周艳,李梓民,扶晓明,朱新英,袁萍,李东阳.葛根异黄酮对去卵巢大鼠骨密度及骨钙含量的影响.[J].中南医学科学杂志.,2008,(3):.
葛根异黄酮对去卵巢大鼠骨密度及骨钙含量的影响
Effects of Total Isoflavones of Pueraria on Bone Mineral Density and Histomorphology in Ovariectomized Rats
  
DOI:
中文关键词:  葛根异黄酮  大鼠  骨密度  骨钙  骨质疏松症
英文关键词:Pueraria soflavo  rat  bone mineral  density  osteoporosis  
基金项目:
周艳  李梓民  扶晓明  朱新英  袁萍  李东阳
[1]南华大学公共卫生学院,湖南衡阳421001 [2]湖南省疾病预防控制中心,湖南衡阳421001 [3]解放军169医院骨外科,湖南衡阳421001 [4]长沙医学院衡阳校区,湖南衡阳421001
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中文摘要:
      目的 观察葛根异黄酮对去卵巢大鼠骨密度及骨钙含量的影响,为绝经后骨质疏松的防治提供一定的实验依据.方法 40只SD健康雌性大鼠切除双侧卵巢建立骨质疏松症模型后随机分成4组,每组10只,即:模型对照组(生理盐水);高剂量组(葛根异黄酮100 mg/kg);中剂量组(葛根异黄酮50 mg/kg)和低剂量组(葛根异黄酮25 mg/kg)灌胃,每天一次,共3个月,观察葛根异黄酮对去卵巢大鼠骨密度及骨钙含量的影响.结果 葛根异黄酮在100 mg/kg、50 mg/kg组对大鼠的股骨远心端骨密度、股骨中点骨密度、骨钙含量、干股骨重及体重高于模型对照组(P<0.05).结论 适量葛根异黄酮对卵巢切除大鼠骨质疏松症有防治作用.
英文摘要:
      Objective To observe the effects of total isof lavones of Pueraria on bone mineral density and Histomorphology in ovariectomized rats,in order to provides proofs from the laboratory for the prevention and cure of post-menopause osteoporosis. Method Rats were ovariectomized bilaterally under anesthesia to establish animal models of osteoporosis and orally administrated with TIP 100and 50 and 25 mg/Kg/d respectively for 3 months.The effects of total isoflavones of Pueraria on bone mineral density and Histomor...
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