| 何茜萌.雷贝拉唑与奥美拉唑对十二指肠溃疡的短期疗效.[J].中南医学科学杂志.,2007,(4):582-584. |
| 雷贝拉唑与奥美拉唑对十二指肠溃疡的短期疗效 |
| The Short Term Effect of Rabeprazole Versus Omeprazole on Symptom Relief of Duodenal Ulcer |
| 投稿时间：2007-03-08 |
| DOI： |
| 中文关键词: 雷贝拉唑 十二指肠溃疡 奥美拉唑 短期疗效 雷贝拉唑 奥美拉唑 十二指肠溃疡 短期疗效 Duodenal Ulcer Relief Symptom Omeprazole Rabeprazole Effect Term 应用 缓解作用 发生 不良反应 时间 缓解率 用药 消失率 差异 |
| 英文关键词:omeprazole duodenal ulcer rabeprazole |
| 基金项目: |
| 何茜萌 |
| 郴州市第一人民医院消化内科 湖南郴州423000 |
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| 中文摘要: |
| 目的 评价应用雷贝拉唑与奥美拉唑对十二指肠溃疡(DU)患者症状缓解的短期疗效及其安全性.方法 随机双盲平行对照研究.将活动期DU患者随机分为雷贝拉唑(10 mg/天)治疗组与奥美拉唑(20 mg/天)对照组,2组均服药7天.观察指标为腹痛、腹胀、反酸和嗳气的缓解及药物安全性评价.结果 对照组和治疗组分别完成了108例和103例患者的观察.治疗组腹痛平均消失天数为3.1±1.7天,与对照组3.2±1.8天无差异.治疗组和对照组服药期间每天腹痛消失率无明显差异.用药第1天时治疗组腹痛缓解率为56%,明显高于对照组33%(P＜0.05),其余时间内2组间无差异.治疗组第7天的反酸消失率为100%,明显高于对照组83%(P＜0.05).2组患者每天腹胀和嗳气的消失率差异均无显著性.2组均无不良反应发生.结论 雷贝拉唑与奥美拉唑均对Du患者的症状具有良好的治疗作用,而雷贝拉唑在服药第1天对腹痛及第7天对反酸的缓解作用更为明显.雷贝拉唑短期应用具有良好的安全性. |
| 英文摘要: |
| Objective To evaluate the thrapeutic effect and safety of rabeprazole and omeprazole on duodenal ulcer symptoms. Methods This is a multicenter,randomized,double-blind,controlled trial.Patients with active duodenal ulcer were devided into group A treated with rabeprazole 10 mg/day and group B treated with omeprazole 20 mg/day.The duration of treatment was 7 days in both groups.All the symptoms including abdominal pain,acid regurgitation,belching and abdminal bloatness were evaluated before and during the treatment.Result All patients enrolled in group A(108 cases) and group B(103 cases) went through the study.Between the two groups,there were no difference in the mean time of partial and complete pain relief rates every day.The partial pain relief rate on day one was higher in group A(56%) than that in group B(33%,P<0.05).On day seven,acid regurgitation relief rate was higher in group A than that in group B(100% and 83%,respectively,P<0.05).No significant difference in the rate of partial pain relief and acid regurgitation on the other days of the treatment.The relief rate of abdominal bloatness and belching everyday in two groups were similar.No adverse events took place in both groups.Conclusions Rabeprazole(10 mg/day) has excellent therapeuitc effect on the symtoms of duodenal ulcer patients.The effects on the relief of pain and acid regurgitation are better than those of omeprazole.Rabeprazole for short term using is safe. |
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