| 肖启亮,冯伟,陈叶.患儿血清嗜酸细胞趋化因子、可溶性细胞间粘附分子-1的检测.[J].中南医学科学杂志.,2007,(3):383-385. |
| 患儿血清嗜酸细胞趋化因子、可溶性细胞间粘附分子-1的检测 |
| Clinical Significance of Detecting Eotaxin、SicAm- 1 Asthma in Children |
| 投稿时间：2007-02-23 |
| DOI： |
| 中文关键词: 嗜酸细胞趋化因子 可溶性细胞间粘附分子-1 哮喘 |
| 英文关键词:Eotaxin SIcAm- 1 asthma |
| 基金项目: |
| 肖启亮 冯伟 陈叶 |
| 南华大学第二附属医院,湖南衡阳421001 |
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| 中文摘要: |
| 目的 探讨哮喘患儿血清嗜酸细胞趋化因子(Eotaxin)、可溶性细胞间粘附分子-1(SIcAm-1)水平相关性及临床意义.方法 哮喘患儿30例,采用双抗体夹心酶联免疫吸附试验(SELISA)测定其血清Eotaxin、SIcAm-1质量浓度.结果 哮喘患儿急性期血清中Eotaxin高于对照组(P＜0.01)及间歇组(P＜0.01),间歇期也高于对照组(P＜0.05).哮喘患儿急性期血清中SIcAm-1高于对照组(P＜0.01)及间歇组(P＜0.01),间歇期也高于对照组(P＜0.05).Eotaxin、SIcAm-1血清水平存在相关性(P＜0.01).结论 Eotaxin、SIcAm-1参与小儿哮喘病理过程,可作为哮喘病气道炎症诊断的重要指标. |
| 英文摘要: |
| Objective To investigate relationships between plasma levels of Eotaxin and SIcAm-1 in patients with asthma and clinical significance in children.Methods A total of 30 cases of asthma in children were allocated,and the Eotaxin and SIcAm-1 levels were measured by sandwich ELISA.Results The plasma levels of Eotaxin were significantly increased in patients with asthma at the acute period compared with the control group(P<0.01)and intermission group(P<0.01);and significantly increased at intermission group compared with the control group(P<0.01).The plasma levels of SIcAm-1 were significantly increased in patients with asthma at the acute period compared with the control group(P<0.01)and intermission group(P<0.01);and significantly increased at intermission group compared with the control group(P<0.05).There were correlations between the plasma levels of Eotaxin and SIcAm-1.Conclusion Eotaxin and SIcAm-1 levels participated in children patients with asthma course,and were regarded as an important index of airway inflammation diagnoses. |
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