| 邹飞燕,罗志刚,高天舒,黄江波.基质金属蛋白酶-2在膀胱移行细胞癌组织中的表达及临床意义.[J].中南医学科学杂志.,2007,(1):23-26. |
| 基质金属蛋白酶-2在膀胱移行细胞癌组织中的表达及临床意义 |
| Expression of Matrix Metalloproteinase-2 and the Potiented Clinical Implications in Human Bladder Transitional Cell Carcinoma |
| 投稿时间：2006-09-03 |
| DOI： |
| 中文关键词: 膀胱移行上皮细胞癌 基质金属蛋白酶-2 侵袭 质金属蛋白酶 膀胱肿瘤 膀胱移行细胞癌 癌组织 阳性表达率 临床监控 意义 Transitional Cell Carcinoma Bladder Human Implications Clinical Matrix 作用 生物学过程 移行上皮细胞癌 相关 表达阳性 发现 正常膀胱组织 |
| 英文关键词:bladder transitional cell carcinoma MMP- 2 invasion |
| 基金项目:湖南省教育厅科研项目 |
| 邹飞燕 罗志刚 高天舒 黄江波 |
| [1]南华大学医学院外科学教研室,湖南衡阳421001 [2]南华大学第二附属医院泌尿外科,湖南衡阳421001 |
| 摘要点击次数: 856 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的 检测膀胱移行细胞癌(BTCC)组织中MMP-2的表达情况,初步探讨MMP-2在膀胱移行细胞癌中表达的可能临床意义.方法 应用免疫组织化学检测膀胱移行细胞癌组织中MMP-2的蛋白表达,并分析其表达与肿瘤临床分期、病理分级及复发的关系.结果 12例正常膀胱组织未发现MMP-2阳性表达,57例膀胱移行细胞癌组织中有28例MMP-2表达阳性,阳性表达率为49.12%.其表达与肿瘤的病理分级和临床分期明显相关.结论 在膀胱移行细胞癌中,MMP-2的表达均明显上调, MMP-2在膀胱移行上皮细胞癌的侵袭等生物学过程中具有重要的作用,MMP-2可能可以用于临床监控膀胱肿瘤的进展. |
| 英文摘要: |
| Objective To investigate the clinic pathological significance of matrix metalloproteinase-2(MMP-2) expression in bladder transitional cell carcinoma.Methods Expressions of MMP-2 protein were investigated by means of immunohistochemistry in 57 bladder transitional cell carcinoma tissues and 12 normal bladder tissues.The relationship between MMP-2 expression and various clinicopathological parameters including pathological grade and clinical stage was analyzed.Results Immunohistochemicaly,over-expression of MMP2 was frequently(28 of 57 cases,49.12%) detected in BTCC,whereas no MMP-2 expressions in the 12 normal bladder tissues.MMP-2 expression was significantly associated with invasive bladder cancer(Tis-T1 versus T2-T4,P=0.020)and with increased pathological grade.Conclusion Expressions of MMP-2 protein is closely correlated to invasion of BTCC.MMP-2 may play a critical role in occurrence and development of bladder carcinoma. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|