| 肖明,周柏林,桂庆军,王北冰,沈元琼,陈扬勤,谢翠娥,尹凯,李熠.幽门螺杆菌清除治疗对反流性食管炎疗效的影响.[J].中南医学科学杂志.,2006,(4):569-571. |
| 幽门螺杆菌清除治疗对反流性食管炎疗效的影响 |
| Effect of Eradication Therapy for Helicobacter Pylori on Reflux Esophagitis |
| 修订日期：2006-04-27 |
| DOI： |
| 中文关键词: 幽门螺杆菌 反流性食管炎 治疗 |
| 英文关键词:helicobacter pylori,reflux esophagitis,therapy |
| 基金项目: |
| 肖明 周柏林 桂庆军 王北冰 沈元琼 陈扬勤 谢翠娥 尹凯 李熠 |
| [1]永州职业技术学院附属医院,湖南永州425006 [2]湖南省东安县人民医院,湖南永州425006 [3]南华大学医学院,湖南永州425006 |
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| 中文摘要: |
| 目的探讨幽门螺杆菌（Hp）清除治疗对反流性食管炎（RE）疗效的影响。方法将已确诊的58例Hp阳性的RE病人随机分为两组。其中观察组30例，对照组28例。两组病人均给予口服质子泵抑制剂和对症治疗，观察组在治疗的同时加用克拉霉素和阿莫西林作Hp抗菌治疗，对照组则不作Hp抗菌治疗。总疗程均为4周。疗程结束后比较两组病人的症状、胃镜下黏膜损害的改善程度。结果两组病人的症状改善程度差异无显著性，胃镜下黏膜损害改善程度差异亦无显著性。结论清除Hp与否对于RE病人，无论是临床症状的控制，还是黏膜损害性病变的改善并不产生显著影响。 |
| 英文摘要: |
| Objective To investigate the effect of eradication therapy for helicobacter pylori on reflux esophagitis.Methods Fifty-eight patients with reflux esophagitis accompanied by Helicobacter pylori were randomly divided into two groups,30 cases in observation group and 28 cases in control group.H(+)-pump inhibitor were administrated in two groups for 4 weeks,in addition,eradication therapy by clarithromycin and amoxicillin for helicobacter pylori in observation group,not in control group.After that,the improvement degree of symptoms and mucosa-damage in gastroscope was compared between two groups.Results The effective rate of heartburn,swallowing pain,retrosternal pain and dysphagia in two groups was 85.7%,89.3%,75.0%,82.1% vs 82.1%,89.3%,82.1%,85.7% and that of mucosa-damage in gastroscope was 89.28% vs 85.71%.Conclusion The eradication therapy for helicobacter pylori on reflux esophagitis has no significant effect in improvement of symptoms and mucosa-damage in gastroscope. |
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