| 陈宏,姜浩,张志伟.核糖体蛋白L6在K562/A02和K562细胞株中的表达差异.[J].中南医学科学杂志.,2006,(4):519-521. |
| 核糖体蛋白L6在K562/A02和K562细胞株中的表达差异 |
| Different Expression of Ribosomal Protein L6 Between K562/A02 and K562 Cell Line |
| 修订日期：2006-04-29 |
| DOI： |
| 中文关键词: 核糖体蛋白L6 细胞株 |
| 英文关键词:K562 K562/A02 |
| 基金项目:湖南省卫生厅科研项目 |
| 陈宏 姜浩 张志伟 |
| [1]南华大学第一附属医院,湖南衡阳421001 [2]南华大学病理教研室,湖南衡阳421001 |
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| 中文摘要: |
| 目的探讨核糖体蛋白L6（ribosomal proteinL6，RPL6）在急性髓细胞性白血病耐药细胞系K562／A02和敏感细胞系K562中的差异表达。方法分别从K562／A02和K562细胞中提取总RNA，以内参对照RT—PCR检测fuPL6基因表达。结果RPL6在飚62／A02细胞中的表达较K562高（P〈0．001）。结论在耐药细胞系K562／A02高表达RPL6可能与白血病耐药有关。 |
| 英文摘要: |
| Objective To study the different expression of ribosomal protein L6(RPL6) between drug-resistant acute myeloblastic leukemia(AML) cell line K562/A02 and drug-sensitive cell line K562.Method Total RNA was extracted from K562/A02 and K562 cell,and RPL6 mRNA was detected by internal control RT-PCR.Result Internal control RT-PCR showed higher expression of RPL6 in K562/A02 than in K562(P<0.001).Conclusion High expression of RPL6 in drug-resistant K562/A02 cell has relationship with multi-drug resistance in AML. |
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