| 蔡曼波,李建军,尹卫东,张弛,肖俊霞,李勤凯,侯洪杰,刘毅.NO-1886对高糖/高脂/高胆固醇饲养的小型猪血浆C-反应蛋白水平的影响.[J].中南医学科学杂志.,2006,(3):343-346. |
| NO-1886对高糖/高脂/高胆固醇饲养的小型猪血浆C-反应蛋白水平的影响 |
| Effects of NO-1886 on Plasma C-reactive Protein in Highfat/highsucrose/highCholesterol Dietfed Miniature Pigs |
| 修订日期：2006-03-20 |
| DOI： |
| 中文关键词: 脂蛋白酯酶 C-反应蛋白 |
| 英文关键词:NO-1886 |
| 基金项目: |
| 蔡曼波 李建军 尹卫东 张弛 肖俊霞 李勤凯 侯洪杰 刘毅 |
| [1]南华大学心血管病研究所,湖南衡阳421001 [2]南华大学护理学院,湖南衡阳421001 [3]南华大学第二附属医院肾移植中心,湖南衡阳421001 [4]南华大学机能实验中心,湖南衡阳421001 [5]南华大学附属南华医院病理科,湖南衡阳421001 |
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| 中文摘要: |
| 目的探讨NO-1886对高糖／高脂／高胆固醇饲养的小型猪血浆炎症标志物C-反应蛋白水平的影响。方法15只雄性巴马小型猪分成3组，分别饲以正常饮食，高脂／高糖／高胆固醇（HFSCD）和高脂／高糖／高胆固醇加1％NO-1886饮食（HFSCD＋NO-1886）5个月，每两周称一次体重，每月末抽血测定C-反应蛋白的浓度，5月末处死动物后取腹膜后脂肪、大网膜、肠系膜脂肪测定其相对重量。结果HFSCD饲养的小型猪体重明显增加，尤其是腹膜后脂肪、大网膜和肠系膜的脂肪重量显著增加，并且血浆C-反应蛋白水平明显升高；在HFSCD中加入NO-1886明显减轻了小型猪的体重增加，抑制脂肪的异位蓄积，降低了血浆C-反应蛋白的浓度。结论NO-1886可以明显降低高脂／高糖／高胆固醇饲养的小型猪血浆C-反应蛋白的水平升高。 |
| 英文摘要: |
| Objective To ascertain whether NO-1886 has beneficial action in plasma C-reactive protein in high-fat/high-sucrose/high-cholesterol diet(HFSCD)-fed miniature pigs.Methods Male,fifteen Bama-miniature pigs were fed for 5 months on a control diet or a HFSCD with,or without NO-1886(1.0%).Body weights were recorded every two weeks.Plasma C-reactive protein was measured monthly.The pigs were sacrificed at the end of month 5 and the amounts of retroperitoneal,epiploon,and mesenteric fats weight were compared.Results The body weights of HFSCD miniature pigs were markedly elevated with time,especially the amounts of retroperitoneal,epiploon,and mesenteric fats(g/kg body weight) were significantly increased.The plasma C-reactive protein also significantly increased in HFSCD group.Whereas supplementing HFSCD with 1% NO-1886 inhibited body weight gain throughout the study,decreasing abdominal fat accumulation and decreasing plasma C-reactive protein.Conclusion These results indicate that long-term administration of NO-1886 may have a beneficial effect on plasma C-reactive protein in HFSCD-fed miniature pigs. |
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