| 旷昕,黄艳.乌司他丁对体外循环心脏病人血浆cTnl的影响.[J].中南医学科学杂志.,2006,(2):213-214,241. |
| 乌司他丁对体外循环心脏病人血浆cTnl的影响 |
| Influence of Ulinastin on the release of Concentration of cTnl in Plasma after Cardiopulmonary Bypass |
| 投稿时间：2006-01-24 |
| DOI： |
| 中文关键词: 乌司他丁 心肺转流术 肌钙蛋白 心肌缺血 再灌注损伤 |
| 英文关键词:ulinastin cardiopulmonary bypass cardiae troponin heart muscle ischemia reperfusion injury |
| 基金项目: |
| 旷昕 黄艳 |
| 南华大学第一附属医院麻醉科,湖南衡阳421001 |
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| 中文摘要: |
| 目的 观察体外循环（CPB）中预充乌司他丁对CPB心脏病人血浆cTnI的影响。方法 选择40例主动脉阻断时间在30min以上的心脏直视手术患者随机分为两组，实验组和对照组各20例。实验组在常规CPB预充液中加入乌司他丁1．5万u／kg，对照组用生理盐水。分别在CPB前（T1），开放升主动脉时（T2），开放升主动脉30min（T3），术毕12h（T4），术毕24h（R），抽取桡动脉血，测定血浆cTnI的浓度。结果 实验组患者cTnI在T3、T4、T5血浆浓度明显低于对照组（P〈0．01）。结论 乌司他丁可明显减少CPB术后cTnI的释放，对心肌缺血再灌注有保护作用。 |
| 英文摘要: |
| Objective To investigate influence of ulinastin on the release of concentration of cTnl in plasma after Cardiopulmonary Bypass.Methods Forty patients scheduled for cardiac surgery under 30 min following CPB were randomly divided into two groups.In treated group(n=20),ulinastin was added into the prine before CPB.but in control group(n=20),saline was added.Blood samples were drawn from the vadial artery at the following intervals:before CPB(T_1),declamping of aorta(T_2),30 min after declamping of aorta(T_3),12 h after CPB(T_4),24 h after CPB(T_5).the concentration of cTnI in plasma level were measured.Results cTnI in the treated groups were significantly lower than those in the control group at T_3,T_4,T_5(P<0.01).Conclusion Ulinastin can decrease the concentration of cTnI in plasma after CPB and may alleviate heart muscle ischemia reperfusion injury during cardiopulmonary bypass. |
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